News & Events

The RMS Award aknowledges Florian Mair for his outstanding scientific achievements applying flow cytometry in the field of immunology.

Findings of Holzner et al. identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and overlapping functions.

Cullot et al. shows that genome editing with the DNA-PKcs inhibitor AZD7648, which enhances CRISPR-Cas9 directed homology-directed repair efficiencies, causes frequent large-scale genomic alterations. This promtes caution in deploying AZD7648, and reinforces the need to investigate multiple type of potential editig outcomes.

Stefanova et al. identified FGF receptor kinase inhibitors as broad-spectrum antiviral agents, which inhibit the early phase of the viral life cycle. Unexpectedly, their antiviral activity was largely independent of FGF receptor kinase inhibition. Rather, blockade of Src family kinases, in particular Lyn, is mainly responsible for their antiviral effect. These results suggest the poorly studied Lyn kinase as a promising target for the treatment of viral infections.

Prof. Nicola Aceto has been honored for his outstanding commitment to promoting entrepreneurship at ETH Zurich.

Invited speakers: Sara Brown, University of Edinburgh; Liv Eidsmo, Karolinska Institute; Kilian Eyerich, University of Freiburg; Lars French, LMU Munich.

Here we report that Hira and Cdk8 mutations induce rapid loss of one X chromosome in a Mus musculus castaneus hybrid female ESC line that originally maintains two X chromosomes. Our analysis shows that X chromosome loss is not explained by selection of XO cells, but likely driven by a process of chromosome elimination.

Ferrarese/Koch show that loss of FGFR2 in human keratinocytes promotes the expression of pro-inflammatory genes and that expression of FGFR2 itself is downregulated in keratinocytes exposed to pro-inflammatory stimuli, similarly to lesional skin of atopic dermatitis patients.

Karasu et al. discovered that TREX1, an exonuclease, suppresses CRISPR-Cas9-mediated HDR. Modifying DNA repair templates or reducing TREX1 expression before CRISPR genome editing significantly increases HDR efficiencies.

The orgaizing committee of the IMHS Seminar Series "The New Generation Scientists Invite" is pleased to invite you to the  Seminar held by Prof. Johannes Zuber, IMP, Vienna. The Seminar will take place on Monday, 15.07.2024, at 11:00, in the seminar room HPM H33.

Karasu et al. identify CCAR1 as a DNA repair gene via a genome-wide CRISPR. CCAR1 ensures FANCA mRNA splicing by suppressing a poison exon inclusion via U2-type spliceosome in human cells.

Seltmann et al. discovered that the transmembrane protein CLCA2 is transported to the nucleus of keratinocytes via extracellular vesicles (EVs). Nuclear CLCA2 promotes expression of Wnt target genes and is required for the suppression of keratinocyte migration and for survival of these cells under hyperosmotic stress conditions.

Hiebert et al. used a collagen peptide sensor to visualize lysyl oxidase-dependent collagen formation and remodeling during wound healing. The probe selectively detects newly produced or remodeling collagen, but not matured collagen fibers, and can be applied for in vivo wound imaging and for discerning differential remodeling in mice with altered collagen dynamics.  

The orgaizing committee of the IMHS Seminar Series "The New Generation Scientists Invite" is pleased to invite you to the first Seminar held by Dr. Jürgen Knoblich, who pioneered organoid research and is the current director of the IMBA in Vienna. The Seminar will take place on Tuesday, 27.02.2024, at 10:30, in the seminar room HPM H33.

Cords and colleagues report a spatial resolved single-cell imaging mass cytometry analysis of cancer-associated fibroblasts (CAFs) in a non-small cell lung cancer (NSCLC) cohort of 1’070 patients. Their data identify phenotypic and spatial features of CAFs that are associates with patient outcome in NSCLC.

Prof. Dr. Bernhard Payer, Centre of Genomic Regulation (CRB), Barcelona, Spain. Host: Prof. Anton Wutz.

The ETH student association VSETH has recently awarded Prof. Helmuth Gehart with the Golden Owl for best teaching in the Department of Biology, ETH ZUrich, in 2023.

Authors identify TRIM21 as a negative regulator of liver steatosis in nonalcoholic steatohepatitis (NASH) and provides mechanistic insights into an immunometabolic crosstalk that limits fatty acid synthesis and fructose metabolism during metabolic stress. Thus, providing new insights for therapeutic opportunity to treat NASH.

Awarded to scientists who have made important scientific contributions in the area of Endocrinology. 08.11.2023