Publication by Grégoire Cullot et al.: Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.

Cullot et al. shows that genome editing with the DNA-PKcs inhibitor AZD7648, which enhances CRISPR-Cas9 directed homology-directed repair efficiencies, causes frequent large-scale genomic alterations. This promtes caution in deploying AZD7648, and reinforces the need to investigate multiple type of potential editig outcomes.