MHS News Channel
Publication by Matthias Muhar et al.: C-terminal amides mark proteins for degradation via SCF–FBXO31.
Muhar, Farnung et al. show how cells eliminate damaged proteins using SCF–FBXO31, a complex that degrades C-terminally amidated proteins, providing insight into protein quality control and mutations linked to neurodevelopmental disorders.
Publication by Christian Kurzeder et al.: Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial.
Kurzeder et al. demonstrate in a proof-of-concept study that digoxin, an Na+/K+ ATPase inhibitor, reduces circulating tumor cell clusters in metastatic breast cancer patients, supporting further studies with refined inhibitors and clinical endpoints.
Publication by Michael Koch et al.: Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation.
Koch et al. used mice with features resembling Atopic Dermatitis (AD) to study the role of the Nrf2 transcription factor in the AD phenotype. Results reveal a complex role of Nrf2 in the epidermis and show the necessity to optimize the intensity of NRF2 activation for AD treatment.
Florian Mair: 2025 RMS Award for Flow Cytometry
The RMS Award aknowledges Florian Mair for his outstanding scientific achievements applying flow cytometry in the field of immunology.
Publication by Markus Holzner et al.: The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling.
Findings of Holzner et al. identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and overlapping functions.