MHS News Channel
Publication by Sofia Horn et al.: IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia.
Study by Horn et al. reveals different mechanisms by which the multi-functional cytokine IL-1 protects from Candida albicans overgrowth in the kidneys and brain.
Publication by Federica Piattini et al.: IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation.
IL-6 has been associated with protection and pathology to respiratory viral infection. Here we clarify its mechanisms for clearance of influenza virus.
Publication by Andrii Kuklin et al.: An Nrf2-NF-kB cross-talk controls hepatocyte proliferation in the normal and injured liver.
Kuklin et al. show that inducible deletion of two major cytoprotective transcription factors, Nrf2 and NF-kB, in hepatocytes of mice causes spontaneous liver inflammation and necrosis. Functional studies combined with transcriptional profiling identified a cross-talk of these transcription factors in the control of hepatocyte proliferation in the normal and acutely injured liver, which is mediated to a large extent by liver macrophages.
Publication by Matthias Muhar et al.: C-terminal amides mark proteins for degradation via SCF–FBXO31.
Muhar, Farnung et al. show how cells eliminate damaged proteins using SCF–FBXO31, a complex that degrades C-terminally amidated proteins, providing insight into protein quality control and mutations linked to neurodevelopmental disorders.
Publication by Christian Kurzeder et al.: Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial.
Kurzeder et al. demonstrate in a proof-of-concept study that digoxin, an Na+/K+ ATPase inhibitor, reduces circulating tumor cell clusters in metastatic breast cancer patients, supporting further studies with refined inhibitors and clinical endpoints.