MHS News Channel
Florian Mair: 2025 RMS Award for Flow Cytometry
The RMS Award aknowledges Florian Mair for his outstanding scientific achievements applying flow cytometry in the field of immunology.
Publication by Markus Holzner et al.: The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling.
Findings of Holzner et al. identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and overlapping functions.
Publication by Grégoire Cullot et al.: Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.
Cullot et al. shows that genome editing with the DNA-PKcs inhibitor AZD7648, which enhances CRISPR-Cas9 directed homology-directed repair efficiencies, causes frequent large-scale genomic alterations. This promtes caution in deploying AZD7648, and reinforces the need to investigate multiple type of potential editig outcomes.
Publication by Stefanova et al.: FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases.
Stefanova et al. identified FGF receptor kinase inhibitors as broad-spectrum antiviral agents, which inhibit the early phase of the viral life cycle. Unexpectedly, their antiviral activity was largely independent of FGF receptor kinase inhibition. Rather, blockade of Src family kinases, in particular Lyn, is mainly responsible for their antiviral effect. These results suggest the poorly studied Lyn kinase as a promising target for the treatment of viral infections.
Nicola Aceto: Dandelion Entrepreneurship Award 2024
Prof. Nicola Aceto has been honored for his outstanding commitment to promoting entrepreneurship at ETH Zurich.