Eberhart et al. show that systemic peroxisome deficiency results in widespread hypomyelination throughout the central nervous system. This defect is linked to significant metabolic and signaling disruption.
Utilizing large-scale genetic screening and molecular analysis, Aird et al. demonstrated that the proteins SP110 and SP100 interact to regulate the dissolution of PML bodies during mitosis. These findings clarify the mechanisms by which cells mitigate the molecular impact of interferon activation upon viral infection or cancer progression.
Aird & Siegner et al uncovered how cells respond to structurally diverse DNA breaks, identifying ERCC6L2 as a safeguard of staggered DNA double-strand breaks, thereby preventing harmful deletions and chromosomal rearrangements during genome editing.