2024
Mini-Symposium Announcement: “Inflammatory Skin Disease”, 28.11.2024, 13:30-18:00, RAA-G-01, UZH “Kleine Aula”.
Invited speakers: Sara Brown, University of Edinburgh; Liv Eidsmo, Karolinska Institute; Kilian Eyerich, University of Freiburg; Lars French, LMU Munich.
Publication by Kevin Halter & Jingyi Chen et al.: Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
Here we report that Hira and Cdk8 mutations induce rapid loss of one X chromosome in a Mus musculus castaneus hybrid female ESC line that originally maintains two X chromosomes. Our analysis shows that X chromosome loss is not explained by selection of XO cells, but likely driven by a process of chromosome elimination.
Publication by Luca Ferrarese & Michael Koch et al.: Inflammatory mediators suppress FGFR2 expression in human keratinocytes to promote inflammation.
Ferrarese/Koch show that loss of FGFR2 in human keratinocytes promotes the expression of pro-inflammatory genes and that expression of FGFR2 itself is downregulated in keratinocytes exposed to pro-inflammatory stimuli, similarly to lesional skin of atopic dermatitis patients.
Publication by Mehmet Kerasu et al.: Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination.
Karasu et al. discovered that TREX1, an exonuclease, suppresses CRISPR-Cas9-mediated HDR. Modifying DNA repair templates or reducing TREX1 expression before CRISPR genome editing significantly increases HDR efficiencies.
Seminar Announcement: "Unraveling cancer-associated metabolic bottlenecks in vivo" by Prof. Johannes Zuber, IMP, Vienna.
The orgaizing committee of the IMHS Seminar Series "The New Generation Scientists Invite" is pleased to invite you to the Seminar held by Prof. Johannes Zuber, IMP, Vienna. The Seminar will take place on Monday, 15.07.2024, at 11:00, in the seminar room HPM H33.