Publication by Stefanova et al.: FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases.

Stefanova et al. identified FGF receptor kinase inhibitors as broad-spectrum antiviral agents, which inhibit the early phase of the viral life cycle. Unexpectedly, their antiviral activity was largely independent of FGF receptor kinase inhibition. Rather, blockade of Src family kinases, in particular Lyn, is mainly responsible for their antiviral effect. These results suggest the poorly studied Lyn kinase as a promising target for the treatment of viral infections.