Publication by Michael Koch et al.: Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation.

Koch et al. used mice with features resembling Atopic Dermatitis (AD) to study the role of the Nrf2 transcription factor in the AD phenotype. Results reveal a complex role of Nrf2 in the epidermis and show the necessity to optimize the intensity of NRF2 activation for AD treatment.