Publication by Nikolau et al.: Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators.

Authors identify TRIM21 as a negative regulator of liver steatosis in nonalcoholic steatohepatitis (NASH) and provides mechanistic insights into an immunometabolic crosstalk that limits fatty acid synthesis and fructose metabolism during metabolic stress. Thus, providing new insights for therapeutic opportunity to treat NASH.