Publication by Sänger et al.: Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress.

Sänger et al. found that hyperosmotic stress induces expression of serine protease 35 (PRSS35) in skin fibroblasts, affecting the extracellular matrix proteome and limiting cell proliferation. The in vivo relevance of these findings is reflected by the co-expression of PRSS35 and its binding partners in human skin wounds. The results identify PRSS35 as a key regulator of the matrisome under hyperosmotic stress conditions.