Publication by Saini et al.: Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer.

Saini et al. showed that: EPCAM-high cells from metastatic biopsies can propagate breast cancer in vivo; resistance to EMT sustains tumorigenesis and metastatic spread of the human disease; irreversible EMT results in restrained tumorigenic potential in clonal subsets.