Publication by Slabber et al.: The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

Slabber et al. identified the ubiquitin ligase Uhrf2 as a key target of fibroblast growth factor signaling in the regeneration liver and discovered an essential function of Uhrf2 in liver regeneration. Loss of Uhrf2 in hepatocytes increased the production of cholesterol through epigenetic regulation of cholesterol biosynthesis enzymes, resulting in the accumulation of toxic bile acids that caused liver failure after partial hepatectomy.