Publication by Ben-Yehuda Greenwald et al.: Topical wound treatment with a nitric oxide releasing PDE5 inhibitor formulation enhances blood perfusion and promotes healing in mice.

Ben-Yehuda Greenwald et al. investigated the effect of topical application of an NO-releasing phosphodiesterase 5 inhibitor-containing hydrogel on wound repair. The treatment promoted re-epithelialization and angiogenesis in wounds of healthy and healing-impaired diabetic mice. It also increased the microvascular network density and promoted blood perfusion of the wounds. These data encourage its further development as a wound therapeutic.