Publication by Yan et al.: NEDD4-1 is a key regulator of epidermal homeostasis and wound repair.

Yan et al. show that Nedd4-1-deficient keratinocytes failed to efficiently activate the Erk1/2 mitogen-activated kinases and the YAP transcriptional co-activator, resulting in severely delayed wound healing in keratinocyte-specific Nedd4-1 knockout mice.