Publication by Title et al.: The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo.

We show that the double negative feedback loop of miR-200 and Zeb1 is essential for pancreatic b-cell function. Disruption of the miR-200-Zeb1 axis leads to broad transcriptional changes in islets affecting β-cell identity, EMT, insulin secretion and cell-cell junctions. Impaired inhibition of Zeb1 by miR-200 protects against ER stress, and derepression of Zeb1 leads to impaired b-cell aggregation of dissociated islets and insulin secretion.