Publication by Muri et al.: The thioredoxin-1 inhibitor Txnip retrains effector T-cell and germinal center B-cell expansion.

Thioredoxin-1 (Trx1) is a vital component for cellular redox homeostasis. Trx-interacting protein (Txnip) binds to reduced Trx1 and inhibits its activity. However, the role of Txnip in adaptive immunity is unknown. Here, we show that absence of Txnip increased proliferation of T cells and germinal center B cell responses but did not affect their development and homeostasis. Thus, this study further uncovers positive and negative control of lymphocyte proliferation by the Trx1 system.