Publication by Muri et al.: B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

Muri et al. demonstrate that B1 and marginal zone (MZ) B cells but not follicular (Fo) B2 cells require Gpx4 during homeostasis and antibody responses. Mechanistically, B1 and MZ B cells display increased lipid metabolism, sensitivity to lipid peroxidation, and ferroptosis in comparison to Fo B cells.