Selected Publications
For detailed publication lists please refer to each research group
Publication by Fielden & Siegner et al.: Comprehensive interrogation of synthetic lethality in the DNA damage response.
Filden & Siegner et al. used CRISPRi screens to map genetic interactions among core DNA damage response genes, revealing key mechanisms of genome stability and uncovering vulnerabilities with potential for cancer therapy.
Publication by Sofia Horn et al.: IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia.
Study by Horn et al. reveals different mechanisms by which the multi-functional cytokine IL-1 protects from Candida albicans overgrowth in the kidneys and brain.
Publication by Federica Piattini et al.: IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation.
IL-6 has been associated with protection and pathology to respiratory viral infection. Here we clarify its mechanisms for clearance of influenza virus.
Publication by Andrii Kuklin et al.: An Nrf2-NF-kB cross-talk controls hepatocyte proliferation in the normal and injured liver.
Kuklin et al. show that inducible deletion of two major cytoprotective transcription factors, Nrf2 and NF-kB, in hepatocytes of mice causes spontaneous liver inflammation and necrosis. Functional studies combined with transcriptional profiling identified a cross-talk of these transcription factors in the control of hepatocyte proliferation in the normal and acutely injured liver, which is mediated to a large extent by liver macrophages.
Publication by Matthias Muhar et al.: C-terminal amides mark proteins for degradation via SCF–FBXO31.
Muhar, Farnung et al. show how cells eliminate damaged proteins using SCF–FBXO31, a complex that degrades C-terminally amidated proteins, providing insight into protein quality control and mutations linked to neurodevelopmental disorders.