Selected Publications
For detailed publication lists please refer to each research group
Publicatio by Gremmelspacher et al.: Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters.
A recent Nature Genetics paper by the Aceto and Beerenwinkel groups reveals clonal heterogeneity in circulating tumor cell clusters, advancing our understanding of metastasis-relevant clonal dynamics.
Publication by Matsushita & Muri et al.: Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages.
The article shows that peroxisomal lipid metabolism is crucial for mitochondrial fitness, development, and function of lung alveolar macrophages.
Publication by Fielden & Siegner et al.: Comprehensive interrogation of synthetic lethality in the DNA damage response.
Filden & Siegner et al. used CRISPRi screens to map genetic interactions among core DNA damage response genes, revealing key mechanisms of genome stability and uncovering vulnerabilities with potential for cancer therapy.
Publication by Sofia Horn et al.: IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia.
Study by Horn et al. reveals different mechanisms by which the multi-functional cytokine IL-1 protects from Candida albicans overgrowth in the kidneys and brain.
Publication by Federica Piattini et al.: IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation.
IL-6 has been associated with protection and pathology to respiratory viral infection. Here we clarify its mechanisms for clearance of influenza virus.