Koch et al. used mice with features resembling Atopic Dermatitis (AD) to study the role of the Nrf2 transcription factor in the AD phenotype. Results reveal a complex role of Nrf2 in the epidermis and show the necessity to optimize the intensity of NRF2 activation for AD treatment.
Findings of Holzner et al. identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and overlapping functions.
Cullot et al. shows that genome editing with the DNA-PKcs inhibitor AZD7648, which enhances CRISPR-Cas9 directed homology-directed repair efficiencies, causes frequent large-scale genomic alterations. This promtes caution in deploying AZD7648, and reinforces the need to investigate multiple type of potential editig outcomes.