Haploid embryonic stem cells are powerful tools but tend to revert to a diploid state, limiting their use. Di Minin et al. show that this instability arises from a metabolic imbalance caused by altered cell size and mitochondrial density, leading to redox dysregulation. Correcting this imbalance stabilizes the haploid genome and links cellular metabolism to chromosome stability.
Eberhart et al. show that systemic peroxisome deficiency results in widespread hypomyelination throughout the central nervous system. This defect is linked to significant metabolic and signaling disruption.
Utilizing large-scale genetic screening and molecular analysis, Aird et al. demonstrated that the proteins SP110 and SP100 interact to regulate the dissolution of PML bodies during mitosis. These findings clarify the mechanisms by which cells mitigate the molecular impact of interferon activation upon viral infection or cancer progression.