Selected Publications
*Corresponding author(s)
2024
Kristin Seltmann*, Britta Hettich, Seraina Abele, Selina Gurri, Valeria Mantella, Jean-Christophe Leroux and Sabine Werner* (2024). Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration. J. Extracell. Vesicles, in press.
Dennis R. Roop*, Thomas M. Krieg, Sabine Werner, Stuart Yuspa, Kyra Diehl, Riyad Seervai, Tamia Alisha Harris-Tryon, and Sancy Leachman (2024). Montagna Symposium on the Biology of Skin 70th Anniversary: Visualizing the Future! J. Invest. Dermatol., in press.
Paul Hiebert, Giuseppe Antoniazzi, Matthew Aronoff, Sabine Werner* and Helma Wennemers* (2024). A lysyl oxidase-responsive collagen peptide illuminates collagen remodeling in wound healing. Matrix Biol. 128, 11-20. PMID 38382767.
Jessica Polak*, David Sachs, Nino Scherrer, Adrian Süess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt and Costanza Giampietro (2024). Radial matrix constraint influences tissue contraction and promotes maturation of bi-layered skin equivalents. Biomater. Adv. 156, 213702. PMID 37992477.
2023
Selina Gurri, Beat Siegenthaler, Michael Cangkrama, Gaetana Restivo, Marcel Huber, James Saliba, Reinhard Dummer, Volker Blank, Daniel Hohl and Sabine Werner* (2023). NRF3 suppresses squamous carcinogenesis involving the unfolded protein response protein HSPA5. EMBO Mol. Med. e17761. PMID 37807968.
Catharina S. Sänger, Martina Cernakova#, Mateusz S. Wietecha#, Lorenza Garau Paganella, Céline Labouesse, Oksana Dudaryeva, Carole Roubaty, Michael Stumpe, Edoardo Mazza, Mark W. Tibbitt, Jörn Dengjel, and Sabine Werner* (2023). Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress. Sci. Adv. 9: eadh9219. PMID 37647410. #Equal contribution.
Vadim Krivitsky, Adva Krivistsky, Valeria Mantella, Maya Ben-Yehuda Greenwald, Devanarayanan Siva Sankar, Jil Betschmann, Johannes Josua Bader, Nicole Zoretto, Kento Schreier, Sarah Feiss, Dario Walker, Jörn Dengjel, Sabine Werner and Jean-Christophe Leroux* (2023). Ultra-fast and controlled capturing, loading, and release of extracellular vesicles by a portable microstructured electrochemical fluidic device. Adv. Mater., in press. PMID 37452635.
Coenraad Frederik Slabber, Marc Bachofner, Tobias Speicher, Abbie Elisabeth Fearon, Andrii Kuklin, Susagna Padrissa-Altés, Roman Bogorad, Carla Horváth Rudigier, Daria Wüst, Sabrina Krautbauer, Marcus Höring, Gerhard Liebisch, Daniel G. Anderson, Christian Wolfrum, Ulrich auf dem Keller and Sabine Werner* (2023). The ubiquitin ligase Urf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration. Sci. Signal. 16, eade8029. PMID 37253090.
https://www.science.org/stoken/author-tokens/ST-1217/full
Mateusz S. Wietecha*, David Lauenstein, Sybille Rion, Juyoung Jin, Andreas Goppelt, Manfred Claassen, Mitchell Paul Levesque, Reinhard Dummer and Sabine Werner* (2023). Phase-specific signatures of wound fibroblasts and extracellular matrix patterns define cancer-associated fibroblast subtypes and predict cancer outcome. Matrix Biol. 119, 19-56. PMID 36914141.
Salome Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till R. Wüstemann, Heiko Steenbock, Selina Gurri, Fabio Sabino, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller*, Sabine Werner*, and Mattia R. Bordoli* (2023). Mesenchyme-derived vertebrate lonesome kinase controls extracellular matrix composition and organogenesis of the lung. Cell. Mol. Life Sci. 80, 89. PMID 36920550.
Remy Vu, Morgan Dragan, Peng Sun, Sabine Werner and Xing Dai* (2023). Epithelial-mesenchymal plasticity and endothelial-mesenchymal transition in cutaneous wound healing. Cold Spring Harb. Perspect Biol., in press. PMID 36617638
Lorenz M. Brunner, Yuliang He, Nikola Cousin, Jeannette Scholl, Llivia Albin, Bianca Schmucki, Sandrin Supersaxo, Gaetana Restivo, Jürg Hafner, Dario Neri, Sabine Werner and Michael Detmar* (2023). Promotion of lymphangiogenesis by targeted delivery of VEGF-C improves diabetic wound healing. Cells 12, 472. PMID 36766814.
Paul Hiebert* and Sabine Werner* (2023). Targeting NRF2 to promote epithelial repair. Biochem. Soc. Trans., in press. PMID 36762597
Sabine Werner* and Maya Ben-Yehuda Greenwald (2023). Wound healing: an orchestrated process of cell cycle, adhesion, and signaling. In: Ralph A. Bradshaw, Gerald W. Hart, and Philip D. Stahl (eds). Encyclopedia of Cell Biology. 2nd edition, vol. 6, 739-747.
2022
Maya Ben-Yehuda Greenwald, Yu-Hang Liu, Weiye Li, Paul Hiebert, Maria Zubair, Hermann Tenor, Tobias Braun, Reto Naef*, Daniel Razansky* and Sabine Werner* (2022). Topical wound treatment with a nitric oxide releasing PDE5 inhibitor formulation enhances blood perfusion and promotes healing in mice. Pharmaceutics, 14, 2358. PMID 36365176.
Paul Hiebert*, Anastasiya Martyts, Jonas Schwestermann, Katharina Janke, Jürg Hafner, Petra Boukamp, Edoardo Mazza and Sabine Werner (2022). Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis. Matrix Biol. 113, 39-60. PMID 36367485
Michael Cangkrama*, Huan Liu, James Whipman, Maria Zubair, Mai Matsushita Azuma, Manfred Kopf, Metello Innocenti*, and Sabine Werner* (2022). A pro-tumorigenic mDia2-MIRO1 axis controls mitochondrial positioning and function in cancer-associated fibroblasts. Cancer Res. 82, 3701-3707. PMID 35997559.
Michael Koch, Tobias Kockmann, Elke Rodriguez, Ulrike Wehkamp, Paul Hiebert, Maya Ben-Yehuda Greenwald, Dora Stölzl, Hans-Dietmar Beer, Erwin Tschachler, Stephan Weidinger+, Sabine Werner+ and Ulrich auf dem Keller+* (2022). Quantitative proteomics identifies reduced NRF2 activity and mitochondrial dysfunction in Atopic Dermatitis. J. Invest. Dermatol., in press. + joint senior authors. PMID 36108803.
Michal Sobecki, Jing Chen, Ewelina Krzywinska, Shunmugam Nagarajan, Zheng Fan, Eric Nelius, Josep M. Monné Rodriguez, Frauke Seehusen, Amro Hussein, Greta Moschini, Edries Y. Hajam, Ravi Kiran, Dagmar Gotthardt, Julien Debbache, Cécile Badoual, Tatsuyuki Sato, Takayuki Isagawa, Norihiko Takeda, Corinne Tanchot, Eric Tartour, Achim Weber, Sabine Werner, Johannes Löffing, Lukas Sommer, Veronika Sexl, Christian Münz, Carol Feghali-Bostwick, Elena Pachera, Oliver Distler, Jess Snedeker, Colin Jamora and Christian Stockmann* (2022). Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell 29, 1-16.
Laura Yerly, Christine Pich-Bavastro, Jeremy Di Domizio, Tania Wyss, Stephanie Tissot, Michael Cangkrama, Michel Gilliet, Sabine Werner and Francois Kuonen* (2022). Integrated multi-omics reveals the cellular and molecular interactions governing the invasive niche in skin cancer. Nat. Commun 13, 4897. PMID 35986012.
Sophia Pantasis, Juliane Friemel, Salome M. Brütsch, Zenan Hu, Sabrina Krautbauer, Gerhard Liebisch, Jörn Dengjel, Achim Weber, Sabine Werner* and Mattia R. Bordoli* (2022). VLK modulates the hepatocyte secretome to prevent perivascular fibrosis and liver inflammation. J Cell Sci. 135, jcs259243. PMID 35293576.
Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel and Manolis Pasparakis (2022). p62 promotes survival and hepatocarcinogenesis in mice with liver-specific NEMO ablation. Cancers 14, 2436. PMID 35626041.
Shen Yan, Raphael Ripamonti, Hiroshi Kawabe, Maya Ben-Yehuda Greenwald* and Sabine Werner* (2022). NEDD4-1 is a key regulator of epidermal homeostasis and wound repair. J. Invest. Dermatol. 142, 1703-1713. PMID 34756879.
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, and Daniel Razansky* (2022). Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds. Theranostics 12, 558-573. PMID 34976201
Maxence Cornille, Stéphanie Moriceau, Roman Hossein Khonsari, Yann Heuzé, Lea Loisay, Valérie Boitez, Anne Morice, Eric Arnaud, Corinne Collet, Morad Bensidhoum, Nabil Kaci, Nathalie Boddaert, Giovanna Paternoster, Theresa Rauschendorfer, Sabine Werner, Suzanne L Mansour, Federico di Rocco, Franck Oury, and Laurence Legeai-Mallet* (2022). FGFR3 over-activation in the brain is responsible for memory impairments in Crouzon syndrome mouse model. J. Exp. Med. 291, e20201879. PMID 35254402.
2021
Abbie A. Fearon+, Coenraad Slabber+, Andrii Kuklin, Marc Bachofner, Luigi Tortola, Lea Pohlmeier, Sophia Pantasis, Thorsten Hornemann, Lin Chen, Manfred Kopf and Sabine Werner* (2021). Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis. iScience 24, 103143. +Joint first authors. PMID 34646985.
Theresa Rauschendorfer, Selina Gurri, Irina Heggli, Luigi Maddaluno, Michael Meyer, Alvaro Inglés-Prieto, Harald Janovjak* and Sabine Werner* (2021). Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Sci. Alliance 4, e202101100. PMID 34548382.
Svitlana Kurinna*, Kristin Seltmann, Andreas L. Bachmann, Andreas Schwendimann, Lalitha Thiagarajan, Hans-Dietmar Beer, Maria Rosaria Mollo, Caterina Missero, and Sabine Werner (2021). Interaction of the Nrf2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis. Nucl. Acids Res. 49, 3748-3763. PMID 33764436.
Johannes Rebling, Maya Ben-Yehuda Greenwald, Mateusz Wietecha, Sabine Werner* and Daniel Razansky* (2021). Long-term imaging of wound angiogenesis with large scale optoacoustic microscopy. Adv. Sci. 202004226.
Matthew R. Aronoff, Paul Hiebert, Nina B. Hentzen, Sabine Werner and Helma Wennemers* (2021). Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide. Nat. Chem. Biol. 17, 865-871.
Maya Ben-Yehuda Greenwald, Carlotta Tacconi, Marko Jukic, Natasha Joshi, Paul Hiebert, Michael Detmar, Herrmann Tenor, Reto Naef and Sabine Werner* (2021). A dual-acting nitric oxide donor and phosphodiesterase inhibitor promotes wound healing in normal mice and in mice with diabetes. J. Invest. Dermatol. 141, 415-426. PMID 32598925.
2020
Michael Cangkrama+, Mateusz Wietecha+ and Sabine Werner* (2020). Wound repair, scar formation and cancer: converging on activin. Trends Mol. Med. 26, 1107-1117. +Joint first authors. PMID 32878730.
Michael Cangkrama* and Sabine Werner* (2020). Genotoxic agents; An unexpected effect on healthy epithelia. Dev. Cell 55, 515-517. (Preview). PMID 33290689
Britta F. Hettich, Maya Ben-Yehuda Greenwald, Sabine Werner, and Jean-Christophe Leroux* (2020). Exosomes for wound healing: purification, optimization and identification of bioactive compounds. Adv. Sci. 7, 2002596. PMID 33304765
Luigi Maddaluno+*, Corinne Urwyler+, Theresa Rauschendorfer+, Michael Meyer, Debora Stefanova, Roman Spörri, Mateusz Wietecha, Luca Ferrarese, Diana Stoycheva, Daniela Bender, Nick Li, Gerhard Strittmatter, Khondokar Nasirujjaman, Hans-Dietmar Beer, Peter Staeheli, Eberhard Hildt, Annette Oxenius and Sabine Werner* (2020). Antagonism of interferon signaling by fibroblast growth factors promotes viral replication. +Joint first authors. EMBO Mol. Med. e11793. PMID 32720440.
Jeremy Di Domizio, Cyrine Belkhodja, Pauline Chenuet, Anissa Fries, Timothy Murray, Paula Marcos Mondejar, Olivier Demaria, Curdin Conrad, Bernhard Homey, Sabine Werner, Daniel E. Speiser, Bernhard Ryffel, and Michel Gilliet* (2020). The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin. Nat. Immunol. 21, 1034-1045. PMID 32661363.
Mateusz Wietecha+, Marco Pensalfini+, Bettina Müller, Michael Cangkrama, Jürgen Brinckmann, Edoardo Mazza* and Sabine Werner* (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome controls the biomechanical properties of skin wounds. Nat. Commun. 10, 2604. PMID 32150356. Selected for Editors’ Highlights webpage of recent research on “Stem cells” (https://www.nature.com/ncomm/editorshighlights).
Sukalp Muzumdar, Michael Koch, Hayley Hiebert, Andreas Bapst, Alessia Gravina, Wilhelm Bloch, Hans-Dietmar Beer, Sabine Werner* and Matthias Schäfer* (2020). Genetic activation of Nrf2 ameliorates disease symptoms in a murine model of Netherton syndrome. Dis. Model Mech. 13, dmm042648. PMID 32457102.
Selected by the journal for a first author interview (“First Person”): Dis Model Mech 13, dmm045146.
Michael Cangkrama*, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Maria Antsiferova, Reinhard Dummer, Metello Innocenti and Sabine Werner* (2020). A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. EMBO Mol. Med., e11466. PMID 27932444.
Highlighted by a News & Views article: Remi Samain and Victoria Sanz-Moreno (2020). Cancer-associated fibroblasts: activin A adds another string to their bow. EMBO Mol. Med., e12102. PMID 27932444.
Natasha Joshi+, Lea Pohlmeier+, Eric Haertel, Maya Ben-Yehuda Greenwald, Manfred Kopf* and Sabine Werner* (2020). Comprehensive characterization of myeloid cells during wound healing of healthy and healing-impaired diabetic mice. Eur. J. Immunol. 50, 1335-1349. +Joint first authors. PMID 32306381.
Michael Meyer, Maya Ben Yehuda Greenwald, Theresa Rauschendorfer, Catharina Sänger, Marko Jukic, Haruka Iizuka, Fumimasa Kubo, Lin Chen, David Ornitz and Sabine Werner* (2020). Mouse genetics identified unique and overlapping functions of FGF receptors in keratinocytes. J. Cell Mol. Med. 24, 1774-1785.
Joohee Lee, Kwangho Song, Paul Hiebert, Sabine Werner, Tae-Gyun Kim and Yeong Shik Kim* (2020). Tussilagonone ameliorates psoriatic features in keratinocytes and imiquimod-induced psoriasis-like lesions in mice via Nrf2 activation. J. Invest. Dermatol. 140, 1223-1232. PMID 31877316.
2019
Paul Hiebert* and Sabine Werner* (2019). Tissue repair: Guarding against friendly fire. Curr. Biol. 29, R1191-R1193.
Paul Hiebert* and Sabine Werner* (2019). Regulation of wound healing by the Nrf2 transcription factor: More than cytoprotection. Int. J. Mol. Sci. 20(16), 3856.
Sukalp Muzumdar, Hayley Hiebert, Eric Haertel, Maya Ben Yehuda Greenwald, Wilhelm Bloch, Sabine Werner, and Matthias Schäfer* (2019). Nrf2-mediated expansion of pilosebaceous cells accelerates cutaneous wound healing. Am. J. Pathol. 189, 568-579. PMID 30593821.
Jennifer Sand, Gabriele Fenini, Serena Grossi, Paulina Hennig, Michela deFilippo, Mitchell Levesque, Sabine Werner, Lars E. French, and Hans-Dietmar Beer* (2019). The NLRP1 inflammasome pathway is silenced in cutaneous squamous cell carcinoma. J. Invest. Dermatol. 139, 1788-1797. PMID 30738816.
Istvan Urban*, Katalin Nagy, Sabine Werner, and Michael Meyer (2019). Evaluation of the combination of strip gingival grafts and a xenogeneic collagen matrix for the treatment of severe mucogingival defects: A human histological study. Int. J Periodontics Restorative Dent. 39, 9-14. PMID 30543721.
2018
Paul Hiebert* and Sabine Werner* (2018). MicroRNA therapy for infected wounds. EMBO Mol. Med. 10, e9574. PMID 30224382.
Paul Hiebert*, Mateusz Wietecha, Michael Cangkrama, Erik Haertel, Eleni Mavrogonatou, Michael Stumpe, Heiko Steenbock, Serena Grossi, Hans-Dietmar Beer, Peter Angel, Jürgen Brinckmann, Dimitris Kletsas, Jörn Dengjel, and Sabine Werner* (2018). Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. Dev. Cell 46, 145-161. PMID 30016619.
Featured article. Selected by the International Society for Matrix Biology for the Rupert Timpl Award 2020.
Kristin Seltmann+, Michael Meyer+, Jitka Sulcova, Tobias Kockmann, Ulrike Wehkamp, Stephan Weidinger, Ulrich auf dem Keller* and Sabine Werner* (2018). Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress. +Equal contribution. Sci. Transl. Med. 10, eaao4650. PMID 29743348.
Paul Hiebert and Sabine Werner*. (2018). Targeting metabolism to treat psoriasis. Nat. Med. 24, 537-539. PMID 29736020.
Bilon Khambu, Nazmul Huda, Xiaoxun Chen, Daniel J. Antoine, Yong Li, Guoli Dai, Ulrike A. Köhler, Zheng Dong, Wie-Xing Zong, Satoshi Waguri, Sabine Werner, Tim D. Oury, and Xiao-Ming Yin* (2018). HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J. Clin. Invest. 128, 2419-2435. PMID 29558368.
Eric Haertel, Natasha Joshi, Paul Hiebert, Manfred Kopf and Sabine Werner* (2018). Regulatory T cells are required for normal and activin-promoted wound repair. Eur. J. Immunol. 48, 1001-1013. PMID 29457218.
Beat Siegenthaler+, Claudia Defila+, Sukalp Muzumdar, Hans-Dietmar Beer, Michael Meyer, Sandra Tanner, Wilhelm Bloch, Volker Blank, Matthias Schäfer and Sabine Werner* (2018). Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion. +Equal contribution. Cell Death Differ. 25: 1749-1765. PMID 29487353.
Jennifer Sand+, Eric Haertel+, Thomas Biedermann, Emmanuel Contassot, Ernst Reichmann, Lars E. French, Sabine Werner, and Hans-Dietmar Beer* (2018). Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes. +Equal contribution. Cell Death Dis. 9: 24. PMID 29348630.
Marco Pensalfini, Eric Haertel, Raoul Hopf, Mateusz Wietecha, Jose M.M. Melero, Sabine Werner and Edoardo Mazza* (2018). The mechanical fingerprint of excisional murine wounds. Acta Biomaterialia 65, 226-236. PMID 29031511.
Vadims Parfejevs, Julien Debbache, Olga Shakhova, Simon Schaefer, Mareen Glausch, Michael Wegner, Ueli Suter, Una Riekstina, Sabine Werner and Lukas Sommer* (2018). Injury-activated glial cells promote wound healing of the adult skin. Nat. Commun. 9: 236. PMID 29339718.
2017
Natasha Joshi and Sabine Werner* (2017). Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice. PLoS One 12(10): e0187162. PMID: 29073253.
Luigi Maddaluno, Corinne Urwyler and Sabine Werner* (2017). Fibroblast growth factors: Key players in regeneration and tissue repair. Development 144, 4047-4060. PMID: 29138288.
Marc Bachofner+, Tobias Speicher+, Roman L. Bogorad, Sukalp Muzumdar, Carina Derrer, Fabrizio Hürlimann, Friederike Böhm, Paolo Nanni, Tobias Kockmann, Ekaterina Kachaylo, Susagna Padrissa-Altés, Michael Meyer, Rolf Graf, Daniel G. Anderson, Victor Koteliansky, Ulrich auf dem Keller* and Sabine Werner* (2017). Large-scale quantitative proteomics identified the ubiquitin ligase Nedd4-1 as an essential regulator of liver regeneration. +Equal contribution. Dev. Cell 42, 616-625. PMID: 28890072. Featured article.
Yannick Boege, Mohsen Malehmir, Marc E. Healy, Kira Bettermann, Anna Lorentzen, Mihael Vucur, Akshay K. Ahuja, Friederike Böhm, Joachim Mertens, Yutaka Shimizu, Lukas Frick, Caroline Remouchamps, Karun Mutreja, Thilo Kähne, Devakumar Sundaravinayagam, Monika Wolf, Hubert Rehrauer, Christiane Koppe, Tobias Speicher, Susagna Padrissa-Altés, Renaud Maire, Jörn M. Schattenberg, Juseong Jeong, Lei Liu, Stefan Zwirner, Regina Boger, Norbert Hüser, Roger J. Davis, Beat Müllhaupt, Holger Moch, Henning Schulze-Bergkamen, Pierre-Alain Clavien, Sabine Werner, Lubor Borsig, Sanjiv A. Luther, Philipp Jost, Ricardo Weinlich, Kristian Unger, Axel Behrens, Laura Hillert, Christopher Dillon, Michela Di Virgilio, David Wallach, Emmanuel Dejardin, Lars Zender, Michael Naumann, Henning Walczak, Douglas R. Green, Massimo Lopes, Inna Lavrik, Tom Luedde, Mathias Heikenwalder*, and Achim Weber*(2017). A dual role of caspase 8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development. Cancer Cell 32, 342-359. PMID: 28898696.
Maria Antsiferova, Aleksandra Piwko-Czuchra, Michael Cangkrama, Mateusz Wietecha, Dilara Sahin, Katharina Birkner, Valerie A. Amann, Mitchell Levesque, Daniel Hohl, Reinhard Dummer and Sabine Werner* (2017). Activin promotes skin carcinogenesis by attraction and re-programming of macrophages. EMBO Mol. Med. 9, 27-45. PMID: 27932444.
Michael Meyer+, Luigi Maddaluno+ and Sabine Werner (2017). Fibroblast growth factors in epithelial homeostasis and repair. In: Fibroblast Growth factors: Biology and Clinical Application. M. Simons ed. World Scientific Press. +Equal contribution.
Martha Garstkiewicz, Gerhard E. Strittmatter, Serena Grossi, Jennifer Sand, Gabriele Fenini, Sabine Werner, Lars E. French, and Hans-Dietmar Beer* (2017). Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression. Eur. J. Immunol. 47,135-147. PMID: 25247911.
Alexandra Gerstgrasser, Hassan Melhem, Irina Leonardi, Kirstin Atrott, Matthias Schäfer, Sabine Werner, Gerhard Rogler and Isabelle Frey-Wagner* (2017). Cell specific activation of the Nrf2 antioxidant pathway increases mucosal inflammation in acute but not chronic colitis. J Crohn`s Colitis 11, 485-499. PMID: 27683801.
2016
Jeannine Wegner, Karin Loser, Gunita Apsite, Roswitha Nischt, Beate Eckes, Thomas Krieg, Sabine Werner and Lydia Sorokin* (2016). Laminin a5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol. 56, 24-41. PMID: 27234307.
Sabine Werner (2016). Krebsentstehung als überschiessende Wundheilung: Verlust einer wichtigen Balance. In: Novo Acta Leopoldina / Acta Historica Leopoldina 412, J. Hacker ed. pp. 231-239.
Svitlana Kurinna+, Sukalp Muzumdar+, Ulrike A. Köhler, Tobias Kockmann, Ulrich auf dem Keller, Matthias Schäfer* and Sabine Werner* (2016). Autocrine and paracrine regulation of keratinocyte proliferation through a novel Nrf2-Il-36g pathway. J. Immunol., 196, 4663-4670. +Joint first authors. *Joint corresponding authors. PMID: 27183581.
Michèle Telorack, Jeannette Abplanalp, and Sabine Werner* (2016). Low levels of glutathione are sufficient for survival of keratinocytes after UV irradiation and for healing of mouse skin wounds. Arch. Dermatol. Res. 308, 443-448. PMID: 27262586.
Marc Bachofner and Sabine Werner* (2016). CAR takes care of the injured liver. Editorial. J. Hepatol. 65, 11-13. PMID: 27057988.
Lung-Yi Lee, Calvin Harberg, Kristina A. Matkowskyi, Shelly Cook, Drew Roenneburg, Sabine Werner, Delinda A. Johnson, Jeffrey A. Johnson, and David P. Foley* (2016). Cell-specific overactivation of Nrf2 in myeloid derived cells within the liver decreases hepatic ischemia reperfusion injury. Liver Transplant. 22, 1115-1128. PMID: 27113842.
Michèle Telorack, Michael Meyer, Irina Ingold, Marcus Conrad, Wilhelm Bloch and Sabine Werner* (2016). A glutathione-Nrf2-thioredoxin cross-talk ensures keratinocyte survival and efficient wound repair. PLOS Genet. 12(1): e1005800. PMID: 26808544.
Ulrike A. Köhler, Friederike Böhm, Frank Rolfs, Michèle Egger-Sigg, Thorsten Hornemann, Manolis Pasparakis, Achim Weber*, and Sabine Werner*. (2016). NF-kB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent liver cell adenoma development. J. Hepatol. 64, 94-102. *Joint corresponding authors. PMID: 26348541.
Lung-Yi Lee, Calvin Harberg, Kristina A. Matkowskyi, Shelly Cook, Drew Roenneburg, Sabine Werner, Jeffrey A. Johnson, and David P. Foley* (2016). Over-activation of the Nrf2-ARE pathway in hepatocytes decreases hepatic ischemia reperfusion injury. Liver Transplant. 22; 91-102. PMID: 26285140.
Andrea S. Link, Svitlana Kurinna, Steven Havlicek, Sandra Lehnert, Martin Reichel, Johannes Kornhuber, Beate Winner, Tobias Huth, Fang Zheng, Sabine Werner, and Christian Alzheimer* (2016). Kdm6b and Pmepa1 as targets of bioelectrically and behaviorally induced activin A signaling. Mol. Neurobiol. 53, 4210-4225. PMID: 26215835.
2015
Frank Rolfs, Marcel Huber, Andreas Kühne, Stefan Kramer, Eric Haertel, Johanna Wagner, Yasmine Tanner, Friederike Böhm, Sigrun Smola, Nicola Zamboni, Reinhard Dummer, Hans-Dietmar Beer, Daniel Hohl, Sabine Werner*, and Matthias Schäfer* (2015). Activation of Nrf2 promotes survival of keratinocytes during skin carcinogenesis via metabolic reprogramming. Cancer Res. 75, 4817-4829. *Joint corresponding authors. PMID: 26530903.
Jitka Sulcova, Luigi Maddaluno, Michael Meyer* and Sabine Werner* (2015). Accumulation and activation of epidermal γδ T in a mouse model of chronic dermatitis is not required for the inflammatory phenotype. Eur. J. Immunol. 45, 2517-2518. *Joint corresponding authors. PMID: 26081170.
Svitlana Kurinna* and Sabine Werner* (2015). Nrf2 and microRNAs: New but awaited relations. Biochem. Soc. Transact. 43, 595-601. * Joint corresponding authors.
Matthias Schäfer* and Sabine Werner* (2015). Nrf2: A regulator of keratinocyte redox signaling. Free Rad. Biol. Med. 88, 243-252. * Joint corresponding authors. PMID: 25912479.
Jitka Sulcova, Michael Meyer, Eva Guiducci, Thorsten Feyerabend, Hans-Reimer Rodewald and Sabine Werner* (2015). Mast cells are dispensable in a genetic mouse model of chronic dermatitis. Am. J. Pathol. 185, 1575-1587. PMID: 25843682.
Matthias Jörg Fuhr+, Michael Meyer+, Eric Fehr, Gilles Ponzio, Sabine Werner*, and Hans Jürgen Herrmann* (2015). A modeling approach to study the effect of cell polarization on keratinocyte migration. PLoS One 10, e0117676. + Joint first authors. * Joint senior and corresponding author. PMID: 25671585.
Susagna Padrissa-Altès, Marc Bachofner, Roman L. Bogorad, Lea Pohlmeier, Thomas Rossolini, Friederike Böhm, Gerhard Liebisch, Claus Hellerbrand, Victor Koteliansky, Tobias Speicher, and Sabine Werner* (2015). Control of hepatocyte proliferation and survival by FGF receptors is essential for liver regeneration in mice. Gut 64, 1444-1453. PMID: 25416068.
2014
Lung-Yi Lee, Ulrike A. Köhler, Li Zhang, Drew Roenneburg, Sabine Werner, Jeffrey A. Johnson, and David P. Foley* (2014). Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice. Toxicol. Sci. 142, 361-374. PMID: 25294219.
Eleonora Elhalem, Rocio Recio, Sabine Werner, Franziska Lieder, José Manuel Calderón-Montaño, Miguel López Lázaro, Inmaculada Fernández, and Nuoreddine Khiar* (2014). Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity. Eur. J. Med. Chem. 87, 552-563. PMID: 25299679.
Svitlana Kurinna, Matthias Schäfer, Paola Ostano, Emmanuel Karouzakis, Giovanna Chiorino, Wilhelm Bloch, Andreas Bachmann, Steffen Gay, David Garrod, Gian-Paolo Dotto, Hans-Dietmar Beer and Sabine Werner* (2014). A novel Nrf2-mir29-desmocollin-2 axis regulates desmosome function in keratinocytes. Nat. Commun., 5, 5099.
Tobias Speicher, Beat Siegenthaler, Roman Bogorad, Raphael Ruppert, Tobias Petzold, Susagna Padrissa-Altes, Marc Bachofner, Daniel G. Anderson, Victor Koteliansky, Reinhard Fässler, and Sabine Werner* (2014). Knockdown and knockout of b1 integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nat. Commun 5:.3869.
Frank Rolfs, Matthias Schäfer and Sabine Werner* (2014). Peroxiredoxin 6 in skin carcinogenesis. Oncoscience 1, 392-393.
Eric Haertel, Sabine Werner* and Matthias Schäfer (2014). Transcriptional regulation of wound inflammation. Sem. Immunol. 26, 321-328.
Matthias Schäfer*, Ann-Helen Willrodt, Svitlana Kurinna, Andrea Link, Hany Farwanah, Alexandra Geusau, Florian Gruber, Olivier Sorg, Aaron J. Huebner, Dennis Roop, Konrad Sandhoff, Jean-Hilaire Saurat, Erwin Tschachler, Marlon R. Schneider, Lutz Langbein, Wilhelm Bloch, Hans-Dietmar Beer, and Sabine Werner (2014). Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease. EMBO Mol. Med. 6, 442-457.
Ulrike A. Köhler, Svitlana Kurinna, Dominik Schwitter, Andrea Marti, Matthias Schäfer, Claus Hellerbrand, Tobias Speicher, and Sabine Werner*. (2014). Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell cycle control and apoptosis. Hepatology 60, 670-678.
Sabine Werner*, Maria Antsiferova and Hans Smola (2014). Linda M McManus, Richard N. Mitchell, editors. Pathobiology of Human Disease. San Diego: Elsevier; 2014. 550-557.
2013
Maria Antsiferova, Caroline Martin, Marcel Huber, Thorsten Feyerabend, Anja Förster, Karin Hartmann, Hans-Reimer Rodewald, Daniel Hohl, and Sabine Werner* (2013). Mast cells are dispensable for normal or activin-promoted wound healing and skin carcinogenesis. J. Immunol., 191, 6147-6155.
Alexandra Montagner, Maria B. Delgado, Corinne Tallichet-Blanc, Jeremy S.K. Chan, Ming K. Sng, Helene Mottaz, Gwendoline Degueurce, Yannick Lippi, Catherine Moret, Michael Baruchet, Maria Antsiferova, Sabine Werner, Daniel Hohl, Talal A. Saati, Pierre Farmer, Nguan S. Tan, Liliane Michalik*, and Walter Wahli* (2013). Src is activated by the nucelar receptor peroxisome proliferator-activated receptor b/d in ultraviolet radiation-induced skin cancer. EMBO Mol Med., 5, 1-19.
Karine Lefort, Yang Brooks, Paola Ostano, Muriel Cario-André, Valérie Calpini, Juan Guinea-Viniegra, Andrea Albinger-Hegyi, Wolfram Hoetzenecker, Ingrid Kolfschoten, Erwin Wagner, Sabine Werner, and G. Paolo Dotto* (2013). A miR-34a-SIRT axis in the squamous cell differentiation network. EMBO J. 32, 2248-2263.
Magdalini Kypriotou, Dianelys Rivero, Marcel Huber, Hans Acha-Orbea, Sabine Werner, and Daniel Hohl* (2013). Activin A inhibits antigen-induced allergy in murine epicutaneous sensitization. Front. Immunol. 4, Article 246; doi: 10.3389/fimmu.2013.00246.
Frank Rolfs, Marcel Huber, Florian Gruber, Friederike Böhm, Valeri N. Bochkov, Erwin Tschachler, Reinhard Dummer, Herbert Pfister, Daniel Hohl, Matthias Schäfer*, and Sabine Werner* (2013). Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis. Cancer Res. 73, 3460-3469.
Anne Walter, Matthias Schäfer, Virginia Cecconi, Claudia Matter, Mirjana Urosevic-Maiwald, Benedetta Belloni, Nicola Schönewolf, Reinhard Dummer, Wilhelm Bloch, Sabine Werner, Hans-Dietmar Beer, Alexander Knuth and Maries van den Broek* (2013). Aldara activates TLR7-independent immune defense. Nat. Commun. 4, 2560.
Marcelo R. Vargas, Neal C. Burton, Li Gan, Delinda A. Johnson, Matthias Schäfer, Sabine Werner, Albee Messing, and Jeffrey A. Johnson* (2013). Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models. PLoS One 8, e56625.
Virginia Hernandez-Gea, Moira Hilscher, Raphael Rozenfeld, Maribel Lim, Natalia Nieto, Sabine Werner, Lakshmi Devi, and Scott Friedma* (2013). Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J. Hepatol., 59, 98-104.
2012
Anna-Katharina Müller+, Michael Meyer+ and Sabine Werner*. The roles of receptor tyrosine kinases and their ligands in the wound repair process. Semin. Cell Dev. Biol. 23, 963-970. +Equal contribution.
Luigi Tortola, Esther Rosenwald, Brian Abel, Hal Blumberg, Matthias Schäfer, Anthony J. Coyle, Jean-Christoph Renauld, Sabine Werner, Jan Kisielow and Manfred Kopf* (2012). Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J. Clin. Invest., 122, 3965-3976.
Aaron J. Huebner, Daisy Dai, Maria Morasso, Edward E. Schmidt, Matthias Schäfer, Sabine Werner and Dennis R. Roop* (2012). Amniotic fluid activates the Nrf2/Keap1 pathway to repair an epidermal barrier defect in utero. Dev. Cell, 23, 1238-1246.
Michael Meyer+, Anna-Katharina Müller+, Jingxuan Yang, Daniel Moik, Gilles Ponzio, David Ornitz, Richard Grose, and Sabine Werner* (2012). FGF receptors 1 and 2 in keratinocytes are key regulators of keratinocyte migration in vitro and in wounded skin. J. Cell Sci., 125, 5690-5701. +Equal contribution.
Franziska Lieder, Felix Reisen+, Tim Geppert+, Gabriel Sollberger, Hans-Dietmar Beer, Ulrich auf dem Keller, Matthias Schäfer, Michael Detmar, Gisbert Schneider, and Sabine Werner* (2012). Identification of UV-protective Nrf2 activators by combining a chemical library screen with computer-based virtual screening. J. Biol. Chem. 287, 33001-33013 . +Equal contribution.
Dustin Singer, Simone M.R. Camargo, Tamara Ramadan, Matthias Schäfer, Luca Marriotta, Brigitte Herzog, Katja Huggel, David Wolfer, Sabine Werner, Josef M. Penninger, and Francois Verrey* (2012). Defective intestinal amino acid absorption in Ace2 null mice (2012). Am. J. Physiol: Gastrointest. Liver Physiol. 303, G686-G695.
Maria Antsiferova and Sabine Werner* (2012). The bright and the dark sides of activin in wound healing and cancer. J. Cell Sci. 125, 3929-3937.
Matthias Schäfer, Hany Farwanah, Ann-Helen Willrodt, Aaron Huebner, Dennis R. Roop, Konrad Sandhoff, Daniel Hohl, Wilhelm Bloch and Sabine Werner* (2012). Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol. Med. 4, 364-379.
Tobias Speicher*, Ulrike Anne Köhler, Alexander Chouker, Sabine Werner, Timo Weiland, and Albrecht Wendel (2012). Fructose protects murine hepatocytes from TNF-induced apoptosis by modulating JNK signaling. J. Biol. Chem. 287, 1837-1846.
2011
Maria Antsiferova, Marcel Huber, Michael Meyer, Aleksandra Piwko-Czuchra, Tamara Ramadan, Amanda S. MacLeod, Wendy L. Havran, Reinhard Dummer, Daniel Hohl and Sabine Werner* (2011). Activin enhances skin tumorigenesis and malignant progression through induction of a pro-tumorigenic immune cell response. Nat. Commun., DOI: 10.1038/ncomms1585.
Sabine Werner* (2011). A novel enhancer of the wound healing process – the fibroblast growth factor binding protein. Commentary. Am. J Pathol. 179, 2144-2147.
Andrei N. Mardaryev, Natalia Meier, Krzysztof Poterlowicz, Andrey A. Sharov, Tatyana Y. Sharova, Mohamed I. Ahmed, Christopher Lewis, Michael Y. Fessing, Thomas M. Ruenger, Jag Bhavan, Sabine Werner, Ralf Paus and Vladimir A. Botchkarev* (2011). Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle-derived progenitor cells to promote epidermal regeneration after injury. Development 138, 4843-4852.
Michael Meyer, Anna-Katharina Müller, Jingxuan Yang, Jitka Sulcova and Sabine Werner* (2011). The role of chronic inflammation in cutaneous fibrosis: Fibroblast growth factor receptor deficiency in keratinocytes as an example. J. Invest. Dermatol. Symp. Proc. 15, 48-52.
Reto Huggenberger, Shoib S. Siddiqui, Daniela Brander, Stefan Ullmann, Kathrin Zimmermann, Maria Antsiferova, Sabine Werner, Kari Alitalo, and Michael Detmar* (2011). An unexpected role of lymphatic vessel activation in limiting acute inflammation. Blood 117, 4667-4778.
Daniel C. Hoffmann, Christine Textoris, Felix Oehme, Tobias Klaassen, Andreas Goppelt, Axel Römer, Burkhard Fugmann, Jeffrey M. Davidson, Sabine Werner, Thomas Krieg and Sabine Eming* (2011). A pivotal role of alpha-1-antichymotrypsin in skin repair. J. Biol. Chem. 286, 28889-28901.
Matthias Schäfer and Sabine Werner (2011). The cornfied envelope: A first line of defense against reactive oxygen species. Commentary. J. Invest. Dermatol. 131, 1409-1411.
2010
Friederike Böhm, Ulrike A. Köhler, Tobias Speicher, and Sabine Werner* (2010). Regulation of liver regeneration by growth factors and cytokines. EMBO Mol. Med. 2, 1-12.
Friederike Böhm, Tobias Speicher, Claus Hellerbrand, Clive Dickson, Juha M. Partanen, David M. Ornitz and Sabine Werner* (2010). FGF receptors 1 and 2 control chemically-induced injury and compound detoxification in regenerating livers of mice. Gastroenterology 139, 1385-1396.
Stephanie Schaedler, Janis Krause, Kiyoshi Himmelsbach, Monica Carvajal-Yepes, Franziska Lieder, Karin Klingel, Michael Nassal, Thomas S. Weiss, Sabine Werner, and Eberhard Hildt* (2010). Hepatitis B virus induces expression of antioxidant response element (ARE)-regulated genes by activation of Nrf2. J. Biol. Chem. 285, 41074-41086.
Matthias Schäfer, Sabine Dütsch, Ulrich auf dem Keller and Sabine Werner* (2010). Nrf2: A central regulator of UV protection in the epidermis. Cell Cycle 9, 2917-2918.
Matthias Schäfer, Sabine Dütsch, Ulrich auf dem Keller, Faterneh Navid, Agatha Schwarz, Delinda A. Johnson, Jeffrey A. Johnson, and Sabine Werner* (2010). Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes & Dev. 24, 1045-1058.
Jingxuan Yang+, Michael Meyer+, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz and Sabine Werner* (2010). FGF receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J. Cell. Biol., 188, 935-952. +:equal contribution.
Laurence Feldmeyer, Sabine Werner, Lars E. French, and Hans-Dietmar Beer* (2010). Interleukin-1, inflammasomes, and the skin. Eur. J. Cell Biol. 89, 638-644.
Maik Dahlhoff, Eckhard Wolf, Anna-Katharina Müller, Sabine Werner, and Marlon Schneider* (2010). Epigen transgenic mice develop enlarged sebaceous glands. J. Invest. Dermatol, 130, 620-622.
2009
Noureddine Khiar, Sabine Werner, Siham Mallouk, Franziska Lieder, Ana Alcudia, and Inmaculada Fernandez* (2009). Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: Asymmetric synthesis and biological activities. J. Org. Chem. 74, 6002-6009.
Aleksandra Piwko-Czuchra, Heidi Kögel, Hannelore Meyer, Martina Bauer, Sabine Werner, Cord Brakebusch, and Reinhard Fässler* (2009). Beta1 integrin-mediated adhesion signaling is crucial for epidermal progenitor cell expansion. PLoS ONE, 4(5):e5488.
Nathalie C. Schlegel, Ossia M. Eichhoff, Silvio Hemmi, Sabine Werner, Reinhard Dummer, and Keith S. Hoeck* (2009). Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells. Pigment Cell Melanoma Res. 22, 445-453.
Heidi Kögel, Lukas von Tobel, Matthias Schäfer, Siegfried Alberti, Elisabeth Kremmer, Cornelia Mauch, Daniel Hohl, Xiao-Jing Wang, Hans-Dietmar Beer, Wilhelm Bloch, Alfred Nordheim and Sabine Werner* (2009). Loss of serum response factor in keratinocytes causes hyperproliferative skin disease. J. Clin. Invest. 119, 899-910.
Samuel Huber, Felix Stahl, Jörg Schrader, Stefan Lüth, Katrin Presser, Antonella Carambia, Richard A. Flavell, Sabine Werner, Manfred Blessing, Johannes Herkel and Christoph Schramm* (2009). Activin A promotes the TGF-beta induced conversion of CD4+CD25- T cells into Foxp3+ iTreg. J. Immunol. 182, 4633-4640.
Maria Antsiferova, Jennifer E. Klöpper, Enikö Bodó, Ralf Paus, José Jorcano, Martin Matzuk, Sabine Werner*, and Heidi Kögel (2009). Epidermal follistatin controls keratinocyte proliferation in normal and wounded skin. Lab. Invest. 89, 131-141.
Fang Zheng, Helmuth Adelsberger, Mischa R. Müller, Jean-Marc Fritschy, Sabine Werner*, and Christian Alzheimer* (2009). Activin tunes GABAergic neurotransmission to modulate anxiety-like behavior. Mol. Psychiatry, 14, 332-346.
2008
Matthias Schäfer and Sabine Werner* (2008). Cancer as an overhealing wound: An old hypothesis revisited. Nat. Rev. Mol. Cell Biol. 9, 628-638.
Matthias Schäfer and Sabine Werner* (2008). Oxidative stress in normal and impaired wound repair. Pharmacol. Res., 58, 165-171.
Weihua Xu, Claus Hellerbrand, Ulrike A. Köhler, Philippe Bugnon, Yuet Wai Kan, Sabine Werner, and Tobias A. Beyer* (2008). The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab. Invest., 88, 1068-1078.
Ekaterina Semenova, Heidi Koegel, Sybille Hasse, Daniel Bilbao, Esfir Slonimski, Ralf Paus, Sabine Werner, and Nadia Rosenthal* (2008). Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am. J. Pathol. 173, 1295-1310.
Geoffrey C. Gurtner, Sabine Werner, Yann Barrandon and Michael T. Longaker* (2008). Wound repair and regeneration. Nature, 453, 314-321.
Tobias A. Beyer and Sabine Werner* (2008). The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver. Cell Cycle, 7, 874-878.
Martin Keller, Andreas Rüegg, Sabine Werner, and Hans-Dietmar Beer* (2008). Active caspase-1 is a regulator of unconventional protein secretion. Cell, 132, 818-831.
Tobias A. Beyer, Weihua Xu, Daniel Teupser, Ulrich auf dem Keller, Philippe Bugnon, Eberhard Hildt, Joachim Thiery, Yuet Wai Kan, and Sabine Werner* (2008). Impaired liver regeneration in Nrf2 knockout mice: Role of ROS-mediated insulin/IGF-1 resistance. EMBO J. 27, 212-223.
Marlon R. Schneider*, Sabine Werner, Ralf Paus and Eckhard Wolf (2008). Beyond wavy hairs: The epidermal growth factor receptor and its ligands in skin biology and pathology. Am. J. Pathol., 163, 14-24.
Marlon Schneider, Maria Antsiferova, Laurence Feldmeyer, Maik Dahlhoff, Philippe Bugnon, Sybille Hasse, Ralf Paus, Eckhard Wolf*, and Sabine Werner* (2008). Delayed hair follicle development and increased blood vessel formation after skin wounding in betacellulin transgenic mice. J. Invest. Dermatol. 128, 1256-1263.
2007
Angelika Kümin, Matthias Schäfer*, Nikolas Epp*, Philippe Bugnon, Christiane Born-Berclaz, Annette Oxenius, Anke Klippel, Wilhelm Bloch and Sabine Werner* (2007). Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J. Cell Biol., 179, 747-760. *Equal contribution.
Klara Brixius, Robert H.G. Schwinger, Felix Hoyer, Andreas Napp, Robert Renner, Birgit Bölck, Angelika Kümin, Uwe Fischer, Uwe Mehlhorn, Sabine Werner, and Wilhelm Bloch* (2007). Isoform-specific downregulation of peroxiredoxins in human failing myocardium. Life Sci. 81, 823-831.
Jose L. de Paz, Christian Noti, Friederike Böhm, Sabine Werner, and Peter H. Seeberger* (2007). Potentiation of Fibroblast Growth Factor activity by synthetic heparin oligosaccharide glycodendrimers. Chem. Biol., 14, 879-887.
Laurence Feldmeyer, Martin Keller, Gisela Niklaus, Daniel Hohl, Sabine Werner, and Hans-Dietmar Beer* (2007). The inflammasome mediates UVB-induced activation and secretion of interleukin-1b by keratinocytes. Curr. Biol. 17, 1140-1145.
Matthias Schäfer and Sabine Werner* (2007). Transcriptional control of wound repair. Ann. Rev. Cell Dev. Biol., 23, 69-92.
Tobias A. Beyer, Ulrich auf dem Keller, Susanne Braun, Matthias Schäfer and Sabine Werner* (2007). Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin disease. Cell Death Differ. 14, 1250-1254.
Meliha Karsak Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, Stefania Petrosino, Katarzyna Starowicz, Regina Steuder, Eberhard Schlicker, Benjamin Cravatt, Raphael Mechoulam, Reinhard Büttner, Sabine Werner, Vincenzo Di Marzo, Thomas Tüting, and Andreas Zimmer* (2007). Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 316, 1494-1497.
Stephanie Papin, Solange Cuenin, Laetitia Agostini, Fabio Martinon, Sabine Werner, Hans-Dietmar Beer, Christian Grutter, Markus Grutter, and Jurg Tschopp* (2007). The SPRY domain of Pyrin, mutated in familial Mediaterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Diff., 14, 1457-1466.
Jolanta Chmielowiec, Malgorzata Borowiak, Markus Morkel, Theresia Stradal, Barbara Munz, Sabine Werner, Jürgen Wehland, Carmen Birchmeier, and Walter Birchmeier* (2007). Met is essential for wound healing in the skin. J. Cell. Biol., 177, 151-162.
Richard Grose, Vera Fantl, Sabine Werner, Athina-Myrto Chioni, Monika Jaroscz, Robert Rudling, Barbara Cross, Ian R. Hart, and Clive Dickson (2007). The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J., 26, 1268-1278.
Sabine Werner, Thomas Krieg and Hans Smola* (2007). Keratinocyte-fibroblast interactions in wound healing. J. Invest. Dermatol., 127, 998-1008.
Sabine A. Eming, Sabine Werner, Philippe Bugnon, Claudia Wickenhauser, Lisa Siewe, Olaf Utermöhlen, Jeffrey Davidson, Thomas Krieg, and Axel Roers* (2007). Accelerated wound closure in mice deficient for interleukin-10. Am. J. Pathol. 107, 188-202.
Sabine Rosenberger, Irmgard Thorey, Sabine Werner, and Petra Boukamp* (2007). A novel regulator of telomerase: S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte cell line HaCaT. J. Biol. Chem., 282, 6126-6125.
Moritz Durchdewald+, Tobias A. Beyer+, Delinda A. Johnson, Jeffrey A. Johnson, Sabine Werner*, and Ulrich auf dem Keller (2007). Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo. J. Invest. Dermatol., 127, 646-653. +Equal contribution.
Stephanie Adams, Sandra Pankow, Sabine Werner and Barbara Munz* (2007). Regulation of NF-kB activity and keratinoyte differentiation by the RIP4 protein; Implications for cutaneous wound repair. J. Invest. Dermatol., 127, 538-544.
Susanne Braun, Cornelia Mauch, Petra Boukamp, and Sabine Werner* (2007). Novel roles of NM23 proteins in skin homeostasis, repair and disease. Oncogene 26, 532-542.
2006
Susanne Braun, Monika Krampert, Enikö Bodó, Christiane Born-Berclaz, Ralf Paus and Sabine Werner* (2006). Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV Irradiation, chemotherapeutic, and cytotoxic agents. J. Cell Sci., 119, 4841-4849.
Suzana Atanasoski, Danielle Boller, Lukas de Ventura, Heidi Kögel, Matthias Böntert, Peter Young, Sabine Werner, and Ueli Suter* (2006). Cell cycle inhibitors p21 and p16 are required for regulation of Schwann cell proliferation. Glia 53, 147-157.
Sandra Pankow, Casimir Bamberger, Anke Klippel, and Sabine Werner* (2006). Phosphatidylinositide 3-kinase: An important regulator of epidermal homeostasis and repair. J. Cell Sci., 119, 4033-4046.
Angelika Kümin, Christine Huber, Thomas Rülicke, Eckhard Wolf and Sabine Werner* (2006). Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am. J. Pathol., 169, 1194-1205
Mischa Müller, Fang Zheng, Sabine Werner*, and Christian Alzheimer* (2006). Forebrain-specific disruption of activin signaling enhances excitotoxicity and impairs synaptic plasticity. J. Biol. Chem. 281, 29076-29084. *Joint senior and corresponding authors.
Ulrich auf dem Keller, Angelika Kümin, Susanne Braun, and Sabine Werner* (2006). Reactive oxygen species and their detoxification in healing skin wounds. J. Invest. Dermatol., 126, Suppl:106-111.
Ulrich auf dem Keller, Marcel Huber, Tobias Beyer, Christina Siemes, Angelika Kümin, Susanne Braun, Philippe Bugnon, Varvara Mitropoulos, Delinda A. Johnson, Jeffrey A. Johnson, Daniel Hohl, and Sabine Werner* (2006). Nrf transcription factors in keratinocytes are crucial for skin tumor prevention but not for wound healing. Mol. Cell Biol., 26, 3773-3784.
Christine Munding+, Martin Keller+, Gisela Niklaus, Stephanie Papin, Jurg Tschopp, Sabine Werner, and Hans-Dietmar Beer* (2006). A novel role of the estrogen-responsive in interleukin-1b secretion. Cell Death Differ., 13, 1938-1949. +Joint first authors.
Diana Rotzer, Monika Krampert, Silke Sulyok, Susanne Braun, Hans-Jürgen Stark, Petra Boukamp, and Sabine Werner* (2006). Id proteins: Novel targets of activin action, which regulate epidermal homeostasis. Oncogene, 25, 2070-2081.
Annette Schmidt, Daniela Wenzel, Irmgard Thorey, Takako Sasaki, Jürgen Hescheler, Rupert Timpl, Klaus Addicks, Sabine Werner, Bernd K. Fleischmann, and Wilhelm Bloch* (2006). Endostatin influences endothelial morphology via the activated ERK1/2-kinase. Microvasc. Res., 71, 152-162. .
Sabine Werner and Christian Alzheimer* (2006). Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokines Growth Factor Rev., 7, 157-171.
2005
Annette Schmidt, Daniela Wenzel, Irmgard Thorey, Sabine Werner, Bernd K. Fleischmann, and Wilhelm Bloch* (2005). Endostatin down-regulates soluble guanylate cyclase (sGC) in endothelial cells in vivo: Influence of endostatin on vascular endothelial growth factor (VEGF) signaling. Endothelium 12, 251-257.
Hans-Dietmar Beer, Michaela Bittner, Gisela Niklaus, Christine Munding, Nicole Max, Andreas Goppelt, and Sabine Werner* (2005). The fibroblast growth factor (FGF) binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: Implications for epithelial repair. Oncogene, 24, 5269-5271.
Monika Krampert, Sandra Künzle, Shelley N.-M. Thai, Nathan Lee, M. Luisa Iruela-Arispe, and Sabine Werner* (2005). ADAMTS1 proteinase is upregulated in wounded skin and regulates migration of fibroblasts. J. Biol. Chem. 280, 23844-23852.
Casimir Bamberger, Agnes Schärer, Maria Antsiferova, Birte Tychsen, Sandra Pankow, Mischa Müller, Thomas Rülicke, Ralf Paus and Sabine Werner* (2005). Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Am. J. Pathol. 167, 733-747.
Lore Florin, Nicole Maas-Szabowski, Sabine Werner, Axel Szabowski, and Peter Angel* (2005). Increased keratinocyte proliferation by c-Jun dependent expression of PTN and SDF-1 in fibroblasts. J. Cell Sci. 118, 1981-1989.
Maria Strassburger, Wilhelm Bloch, Silke Sulyok, Jutta Schüller, Alexander F. Keist, Annette Schmidt, Jutta Wenk, Thorsten Peters, Meinhard Wlaschek, Thomas Krieg, Martin Hafner, Angelika Kümin, Sabine Werner, Werner Müller, and Karin Scharffetter-Kochanek* (2005). Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Rad. Biol. Med. 38, 1458-1470.
Sabine Werner* (2005). Molecular and cellular mechanisms of tissue repair. Exp Dermatol. 10, 786-787.
Sabine Werner and Wolfgang Neubert (2005). Obituary: In memoriam Peter Hans Hofschneider (14.2.1929-23.7.2004). Eur. J. Cell Biol. 84, 5-6.
Armelle Logie, Claire Dunois-Larde, Christophe Rosty, Olivier Levrel, Martine Blanche, Agnes Ribeiro, Jean-Marie Gasc, Jose Jorcano, Sabine Werner, Xavier Sastre-Garau, Jean-Paul Thiery, and Francois Radvanyi* (2005). Activation of the tyrosine kinase receptor FGFR3 is associated with benign skin tumors in mice and humans. Hum. Mol. Genet. 14, 1153-1160.
Patricia Stoitzner, Hella Stössel, Miriam Wankell, Susanne Hofer, Christine Heufler, Sabine Werner, and Nikolaus Romani* (2005). Langerhans cells are strongly reduced in the skin of transgenic mice expressing follistatin in the epidermis. Eur. J. Cell Biol. 84, 733-741.
Casimir Bamberger*, Agnes Schärer, Hartwig Schmale, and Sabine Werner (2005). Expression of different p63 variants in healing skin wounds suggests a role of p63 in reepithelialization and muscle repair. Wound Repair Regen., 13, 41-50.
2004
Wolfgang Neubert* and Sabine Werner (2004). Obituary: In memoriam Peter Hans Hofschneider (1929-2004). Arch. Virol. 149, 2473-2474.
Richard Grose, and Sabine Werner*. (2004). Wound healing studies in transgenic and knockout mice. Mol. Biotechnol. 28, 147-166.
Monika Krampert, Wilhelm Bloch, Takako Sasaki, Philippe Bugnon, Thomas Rülicke, Eckhard Wolf, Monique Aumailley, William C. Parks, and Sabine Werner* (2004). Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol. Biol. Cell, 15, 5242-5254.
Pei-San Tsai, Suzanne M. Moenter, Hector R. Postigo, Mohammed El Majdoubi, Toni R. Pak, John C. Gill, Sreenivasan Paruthiyil, Sabine Werner, and Richard I. Weiner* (2005). Targeted expression of a dominant negative FGF receptor in GnRH neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol. Endocrinol., 19, 225-236.
Xiu-Ping Wang, Marika Suomalainen, Carolina J. Jorgez, Martin Matzuk, Sabine Werner, and Irma Thesleff* (2004). Follistatin inhibits ameloblast differentiation by antagonizing BMP4 signaling and is responsible for the enamel-free area formation in mouse incisors. Dev. Cell, 7, 719-730.
Silke Sulyok, Miriam Wankell, Christian Alzheimer, and Sabine Werner* (2004). Activin; an important regulator of wound repair, fibrosis, and neuroprotection. Mol. Cell. Endocrinol., 225, 127-132.
Thomas Vogl, Stephan Ludwig, Matthias Goebeler, Anke Strey, Irmgard S. Thorey, Rudolf Reichelt, Dirk Foell, Volker Gerke, Wolfgang Nacken, Sabine Werner, Clemens Sorg and Johannes Roth* (2004). Mrp8 and Mrp14 control microtubule reorganization during transendothelial migration of phagocytes. Blood, 104, 4260-4268.
Heike Steiling, Marcus Mühlbauer, Frauke Bataille, Jürgen Schölmerich, Sabine Werner and Claus Hellerbrand* (2004). Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease. Am. J. Pathol., 165, 1233-1241.
Irmgard S. Thorey, Boris Hinz, Andreas Höflich, Susanne Kaesler, Boris Hinz, Philippe Bugnon, Martin Elmlinger, Rüdiger Wanke, Eckhard Wolf, and Sabine Werner* (2004). Transgenic mice overexpressing bovine growth hormone reveal novel activities of growth hormone in wound repair, angiogenesis and myofibroblast differentiation. J. Biol. Chem., 279, 26674-26684.
Lore Florin, Lars Hummerich, Bernd Dittrich, Felix Kokocinski, Gunnar Wrobel, Sabine Gack, Marina Schorpp-Kistner, Sabine Werner, Meinhard Hahn, Peter Lichter, Axel Szabowski, and Peter Angel* (2004). Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing. Oncogene, 3, 7005-7017.
Xiuping Wang, Marika Suomalainen, Carolina J. Jorgez, Martin Matzuk, Miriam Wankell, Sabine Werner, and Irma Thesleff* (2004). Modulation of activin/BMP signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev. Dyn., 231, 98-108.
Ulrich auf dem Keller, Monika Krampert, Angelika Kümin, Susanne Braun, and Sabine Werner* (2004). Keratinocyte growth factor: Effects on keratinocytes and mechanisms of action. Eur. J. Cell Biol., 83, 607-612.
Heike Steilung, Hans-Dietmar Beer, Richard Grose, Tobias A. Beyer, and Sabine Werner*. Keratinocyte growth factors: Important players in epithelial repair processes. In: ETRS Proceedings of the Status of New Technology in Tissue Repair: Growth factors, Gene Therapy, Stem Cells, Tissue Engineering, Physical Forces, Tissue Sealants, Xenotransplantation and Scar Control. G. Cherry (ed.), Positif Press Oxford, UK, in press.
Susanne Braun and Sabine Werner*. Wound Healing. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Ganten, D., and Ruckpaul, K. eds., Springer Verlag, Heidelberg, Germany.
Hongbing Zhang, Jessica Dessimoz, Tobias A. Beyer, Monika Krampert, Lewis T. Williams, Sabine Werner* and Richard Grose (2004). Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing. Eur. J. Cell Biol., 83, 3-11.
Susanne Braun, Ulrich auf dem Keller, Heike Steilung and Sabine Werner* (2004). Fibroblast growth factors in epithelial repair and cytoprotection. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 359, 753-757.
Dieter Seebach*, Kenji Namoto, Yogesh Mahajan, Pascal Bindschädler, Reiner Sustmann, Michael Kirsch, Neil S. Ryder, Markus Weiss, Markus Sauer, Christian Roth, Sabine Werner, Hans-Dietmar Beer, Christine Munding, Peter Walde and Matthias Voser (2004). Chemical and Biological Investigations of b-Oligoarginines. Chemistry and Biodiversity 1, 65-97.
Susanne Kaesler, Philippe Bugnon, Ji-Liang Gao, Philip M. Murphy, Andreas Goppelt, and Sabine Werner* (2004). The chemokine receptor CCR1 is strongly up-regulated after skin injury but dispensable for wound healing. Wound Repair Regen., 12, 193-204.
2003
Heike Steilung and Sabine Werner* (2003). Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection. Curr. Opin. Biotechnol., 14, 533-537.
Miriam Wankell, Silke Werner, Christian Alzheimer and Sabine Werner* (2003). The roles of activin in cytoprotection and tissue repair. Ann. N. Y, Acad. Sci. 995, 48-58.
Heike Steiling, Torsten Wüstefeld, Philippe Bugnon, Maria Brauchle, Reinhard Fässler, Christiane Born-Berclaz, Daniel Teupser, Joachim Thiery, Jeffrey I. Gordon, Christian Trautwein, and Sabine Werner* (2003). FGF receptor signalling is crucial for liver homeostasis and regeneration. Oncogene, 22, 4380-4388.
Richard Grose and Sabine Werner* (2003). Wound healing studies in transgenic and knockout mice. A review. Methods Mol. Med. 78, 191-216.
Tobias Beyer, Sabine Werner, Clive Dickson, and Richard Grose* (2003). Fibroblast growth factor 22 and its possible role in skin development and wound repair. Exp. Cell Res., 287, 228-236.
Sabine Werner* and Richard Grose (2003). Regulation of wound healing by growth factors and cytokines. Physiol. Rev., 83, 835-870.
Motonobu Nakamura, Martin Matzuk, Bernhard Gerstmayer, Andreas Bosio, Roland Lauster, Yoshiki Miyachi, Sabine Werner and Ralf Paus* (2003). Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J. 17, 497-499.
Jan C. Becker, Moritz Hertel, Andre Markmann, Manal Shahin, Sabine Werner, Wolfram Domschke, and Thorsten Pohle* (2003). Dynamics and localization of activin A expression in rat gastric ulcers. Scand. J. Gastroenterol. 38: 260-267.
Heidi Kögel, Susanne Kaesler, Ralf Burgstahler, Sabine Werner and Christian Alzheimer* (2003). Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-EBIO in HaCaT keratinocytes: inverse effects on cell growth and proliferation. J. Biol. Chem. 278: 3323-3330.
Susanne Braun and Sabine Werner* (2003). Wie Wunden heilen. Magazin der Universität Zürich 1/ETH Bulletin 288, 26-28.
Irmgard S. Thorey, Miriam Wankell, Andreas Goppelt and Sabine Werner* (2003). A functional genomics approach to study wound repair: The roles of activin and S100A8/S100A9 in the healing process. In: Falk Symposium 131 – Targets of Treatment in Chronic Inflammatory Bowel Diseases. Symposium Proceedings. H. Herfarth, B.G. Feagan, U.R. Fölsch, J. Schölmerich, M.H. Vatn, and M. Zeitz, (eds). Kluwer Academic Publishers, Dordrecht, Netherlands, pp. 136-144.
2002
Christian Alzheimer* and Sabine Werner (2002). Fibroblast growth factors and neuroprotection. Adv. Exp. Med. Biol. 513, 335-351.
Christiane Kummer, Sven Wehner, Thomas Quast, Sabine Werner and Volker Herzog* (2002). Expression and Potential Function of Alzheimer Amyloid Precursor Proteins during Cutaneous Wound Repair. Exp. Cell Res. 280, 222-232.
Christian Alzheimer* and Sabine Werner (2002). Fibroblast growth factors and neuroprotection. In: Molecular and Cellular Biology of Neuroprotection in the CNS. C. Alzheimer (ed.), Kluwer Academic / Plenum Publishers, Landes Bioscience, pp. 335-345
Susanne Braun, Christine Hanselmann, Marcus Gassmann, Ulrich auf dem Keller, Christiane Born-Berclaz, Kaimin Chan, Yuet Wai Kan, and Sabine Werner* (2002). Nrf2 transcription factor: A novel target of keratinocyte growth factor action which regulates gene expression during cutaneous wound healing. Mol. Cell. Biol. 22, 5492-5505.
Richard Grose, Silke Werner, Daniela Kessler, Jan Tuckermann, Katharina Huggel, Silke Durka, Holger Reichardt, and Sabine Werner* (2002). A role for endogenous glucocorticoids in wound repair. EMBO Reports 3, 575-582.
Moritz Hertel, Susanne Braun, Silke Durka, Christian Alzheimer, and Sabine Werner* (2002). Upregulation and activation of the Nrf-1 transcription factor in the lesioned hippocampus as a novel neuroprotective mechanism against reactive oxygen species. Eur. J. Neurosci. 15, 1707-1711.
Hans-Dietmar Beer, Christine Munding, Nicole Dubois, Céline Mamie, Daniel Hohl and Sabine Werner* (2002). The estrogen-responsive B-box protein: A novel regulator of keratinocyte differentiation. J. Biol. Chem. 277, 20740-20749.
Susanne Braun, Ulrich auf dem Keller, Hans-Dietmar Beer, Monika Krampert, Mischa Müller, Silke Werner, Clive Dickson and Sabine Werner* (2002). Growth factors in development, repair and disease. Futura, 17, 61-70.
Susanne Braun, Ulrich auf dem Keller, Hans-Dietmar Beer, Monika Krampert, Mischa Müller, Silke Werner, Clive Dickson and Sabine Werner* (2002). Growth factors in development, repair and disease. Eur. J. Cell Biol. 81, 375-382.
Richard Grose, Caroline Hutter, Wilhelm Bloch, Fiona Watt, Reinhard Fässler, Cord Brakebusch and Sabine Werner* (2002). A crucial role of b1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development, 129, 2303-2315.
Richard Grose and Sabine Werner* (2002). An aPPARently protective mechanism for keratinocytes in wounded skin. Trends Mol. Med., 8, 149-151.
Sabine Werner (2002). Wundheilung aus molekularbiologischer Sicht. MedReport, 26 (A2), 6.
Susanne Kaesler, Johannes Regenbogen, Silke Durka, Andreas Goppelt, and Sabine Werner *(2002). The healing skin wound: A novel site of action of the chemokine C10. Cytokine, 17, 157-163.
Uwe Schlattner, Natalie Möckli, Oliver Speer, Sabine Werner and Theo Wallimann* (2002). Creatine kinase and creatine transporter in normal, wounded and diseased skin. J. Invest. Dermatol. 118, 416-423.
2001
Miriam Wankell, Barbara Munz, Griseldis Hübner, Wolfgang Hans, Eckhard Wolf, Andreas Goppelt, and Sabine Werner* (2001). Impaired wound healing in transgenic mice expressing the activin antagonist follistatin in the epidermis. EMBO J. 20, 5361-5372.
Silke Werner, Hans-Dietmar Beer, Cornelia Mauch, Bernhard Lüscher, and Sabine Werner* (2001). The Mad1 transcription factor is a novel target of activin and TGF-b action in keratinocytes: Possible role of Mad1 in wound repair and psoriasis. Oncogene, 20, 7494-7504.
Hans Smola*, Sabine A. Eming, Sigrun Hess, Sabine Werner, and Thomas Krieg (2001). Wundheilung und Wundheilungsstörungen. Moderne Konzepte zur Pathophysiologie und Therapie. Deutsches Ärzteblatt 98, A2802-A2809.
Irmgard S. Thorey, Johannes Roth, Johannes Regenbogen, Jörn-Peter Halle, Michaela Bittner, Thomas Vogl, Susanne Kaesler, Philippe Bugnon, Birgit Reitmaier, Silke Durka, Anja Graf, Mandy Wöckner, Norman Rieger, Eckhard Wolf, Andreas Goppelt, and Sabine Werner* (2001). The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J. Biol. Chem., 276, 35818-35825.
Miriam Wankell, Susanne Kaesler, Ya-Qin Zhang, Charles Florence, Sabine Werner*, and Roxanne Duan (2001). The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair. J. Endocrinol., 171, 385-395.
Richard Grose, Monika Krampert and Sabine Werner*. Lessons in transgenic mice for soft tissue healing. In: Textbook of Wound Care. R.A.F. Clark, J. Davidson, T. Mustoe, D. Steed, eds. W.B. Saunders, publisher. In press.
Heike Steiling, Maria Brauchle, Werner Falk and Sabine Werner* (2001). Keratinocyte growth factor, activin, and connective tissue growth factor: Novel players in inflammatory bowel disease. Proceedings of the 113th Falk Symposium: Cytokines and Cell Homeostasis in the Gastrointestinal Tract.
Sabine Werner* and Hans Smola (2001). Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol., 11, 143-146.
Barbara Munz, Yvonne P. Tretter, Moritz Hertel, Felix Engelhardt, Christian Alzheimer, and Sabine Werner* (2001). The roles of activin in repair processes of the skin and the brain. Mol. Cell. Endocrinol. 180, 169-177.
Christine Hanselmann, Cornelia Mauch and Sabine Werner* (2001). Haem oxygenase-1: a novel player in wound repair and psoriasis? Biochem. J., 353, 459-466.
2000
Wilhelm Bloch, Katharina Huggel, Takako Sasaki, Richard Grose, Philippe Bugnon, Klaus Addicks, Rupert Timpl and Sabine Werner* (2000). The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J., 14, 2373-2376.
Cord Brakebusch, Richard Grose, Fabio Quondamatteo, Angel Ramirez, Jose L. Jorcano, Alison Pirro, Marcus Svensson, Rainer Herken, Takako Sasaki, Rupert Timpl, Sabine Werner, and Reinhard Fässler* (2000). Skin and hair follicle integrity is crucially dependent on b1 integrin expression on keratinocytes. EMBO J. 19, 3990-4003.
Hans-Dietmar Beer, Marcus G. Gassmann, Barbara Munz, Heike Steiling, Felix Engelhardt, Kerstin Bleuel, and Sabine Werner* (2000). The roles of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. J. Invest. Dermatol. Symp. Proc. pp. 34-39.
Yvonne Tretter, Moritz Hertel, Barbara Munz, Gerrit ten Bruggencate, Sabine Werner and Christian Alzheimer* (2000). Induction of activin A is essential for the neuroprotective action of bFGF in vivo. Nature Med. 6, 812-815.
Marcus Gassmann and Sabine Werner* (2000). Growth factor regulated expression of caveolins-1 and –2 in cultured keratinocytes and in the regenerating epidermis of cutaneous wounds. Exp. Cell Res., 258, 23-32.
Hans-Dietmar Beer, Laurence Vindevoghel, Mary J. Gait, Jean-Michel Revest, Dah-Shuhn Roxanne Duan, Ivor Mason, Clive Dickson, and Sabine Werner* (2000). Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs which is preferentially expressed in the skin and the brain. J. Biol. Chem. 275, 16091-16097.
Bernhard Reuss, Moritz Hertel, Sabine Werner and Klaus Unsicker* (2000). Fibroblast growth factors –5 and –9 distinctly regulate expression and function of the gap function protein connexin43 in cultured astroglial cells from different brain regions. Glia, 30, 231-241.
Hans-Dietmar Beer, Reinhard Fässler and Sabine Werner* (2000). Glucocorticoid-regulated gene expression during cutaneous wound repair. Vitam. Horm. 59, 217-239.
Paola Castagnino, Matthew V. Lorenzi, Juddi Yeh, Diane Breckenridge, Hiromi Sakata, Barbara Munz, Sabine Werner, and Donald P. Bottaro* (2000). Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors. Oncogene, 19, 640-648.
Silke Werner, Sabine Werner* and Barbara Munz (2000). Suppression of keratin 15 expression by transforming growth factor-b in vitro and by cutaneous injury in vivo. Exp. Cell Res., 254, 80-90.
Moritz Hertel, Yvonne Tretter, Christian Alzheimer, and Sabine Werner* (2000). Connective tissue growth factor: A novel player in tissue reorganization after brain injury. Eur. J. Neurosci, 12, 376-380.
1999
Marcus Gassmann, Andreas Stanzel and Sabine Werner* (1999). Growth factor – regulated expression of enzymes involved in nucleotide biosynthesis: A novel mechanism of growth factor action. Oncogene, 18, 6667-6676.
Hans-Dietmar Beer, Marcus G. Gassmann, Barbara Munz, Heike Steiling, Felix Engelhardt, Kerstin Bleuel, and Sabine Werner* (2000). The roles of keratinocyte growth factor and activin in skin morphogenesis and wound repair. J. Invest. Dermatol. Symposium Proceedings 5, 34-39.
Heike Steiling, Maria Brauchle, Werner Falk and Sabine Werner*. Keratinocyte growth factor, activin, and connective tissue growth factors (2000). Novel players in inflammatory bowel disease. Proceedings of the 113th Falk Symposium: Cytokines and Cell Homeostasis in the Gastrointestinal Tract.
Barbara Munz, Hans Smola, Felix Engelhardt, Kerstin Bleuel, Maria Brauchle, Iris Lein, Lee Ewans, Danny Huylebroeck, Rudi Balling and Sabine Werner* (1999). Overexpression of activin in the epidermis of transgenic mice reveals new activities of activin in keratinocyte differentiation, cutaneous fibrosis and wound repair. EMBO J., 18, 5205-5215.
Griseldis Hübner, Christian Alzheimer und Sabine Werner* (1999). Activin: A novel player in inflammatory processes. Histol. and Histopathol. 14, 295-305.
Barbara Munz, Griseldis Hübner, Yvonne Tretter, Christian Alzheimer and Sabine Werner* (1999). A novel role of activin in inflammation and repair. J. Endocrinol. 161, 187-193.
Heike Steiling, Barbara Munz, Sabine Werner*, and Maria Brauchle (1999). Detoxification of reactive oxygen species during cutaneous wound repair. Exp. Cell Res., 247, 484-494.
Barbara Munz, Martin Wiedmann, Hanns Lochmüller and Sabine Werner* (1999). Cloning of novel wound-regulated genes: Evidence for a role of skNAC in muscle repair. J. Biol. Chem., 274, 13305-13310.
Stefan Frank, Marianne Madlener, Josef Pfeilschifter and Sabine Werner* (1998). Induction of inducible nitric-oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzmye GTP-cyclohydrolase I during cutaneous wound repair. J. Invest. Dermatol., 111, 1058-1064.
1998
Johanna Dammeier, Hans-Dietmar Beer, Maria Brauchle and Sabine Werner* (1998). Dexamethasone is a novel potent inducer of connective tissue growth factor expression: Implications for glucocorticoid therapy. J. Biol. Chem., 273, 18185-18190.
Marianne Madlener, William C. Parks and Sabine Werner* (1998). Matrix metalloproteinases, including metalloelastase, and their physiological inhibitors are differentially expressed during excisional skin wound repair in mice. Exp. Cell Res., 242, 201-210.
Johanna Dammeier, Maria Brauchle, Werner Falk, Gary Grotendorst and Sabine Werner* (1998). Connective tissue growth factor: A novel regulator of mucosal repair and fibrosis in inflammatory bowel disease? Intern. J. Biochem. Cell Biol. 30, 909-922.
Sabine Werner* (1998). Defining growth factor function through tissue-specific expression of dominant-negative receptor mutants. In: Growth factors and receptors: A practical approach. I.A. McKay, K.D. Brown eds. Oxford University Press, pp. 175-197.
Sabine Werner* (1998). The role of fibroblast growth factors in skin morphogenesis and wound repair. In: Epithelial morphogenesis in development and disease. C. Birchmeier, W. Birchmeier eds. Harwood Academic Publishers GMBH., pp. 233-259.
Sabine Werner* (1998). Keratinocyte growth factor: A unique player in epithelial repair processes. Cytokine & Growth Factor Reviews 9, 153-165.
Barbara Munz und Sabine Werner* (1998). Molekularbiologische Kenntnisse zur Wundheilung und praktische Folgerung. Langenbecks Archiv für Chirurgie, Suppl. II, 678-682.
1997
Stefan Frank, Barbara Munz und Sabine Werner* (1997). The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor - regulated gene. Oncogene 14, 915-921.
Sabine Werner*, Maria Brauchle, Stefan Frank and Griseldis Hübner (1997). The role of keratinocyte growth factor in wound repair. In: Progress in Developmental Toxicology and Biology. S. Klug, R. Thiel, eds. Blackwell Science Ltd, pp. 195-208.
Barbara Munz, Stefan Frank, Griseldis Hübner, Eydfinnur Olsen and Sabine Werner* (1997). A novel type of glutathione peroxidase: Expression and regulation during wound repair. Biochem. J. 326, 579-585.
Barbara Munz, Volker Gerke, Reinhard Gillitzer and Sabine Werner* (1997). Differential regulation of annexin II and p11 in cultured keratinocytes and during wound healing. J. Invest. Dermatol. 108, 307-312.
Hans-Dietmar Beer, Michael T. Longaker and Sabine Werner* (1997). Reduced expression of PDGF and PDGF receptors during impaired wound healing. J. Invest. Dermatol. 109, 132-138.
Hans-Dietmar Beer, Charles Florence, Johanna Dammeier, Linda McGuire, Sabine Werner*, and D. Roxanne Duan (1997). Mouse keratinocyte growth factor 2: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene, 15, 2211-2218.
Adrianne L. Wong, Zishan A. Haroon, Sabine Werner, Mark W. Dewhirst, Charles S. Greenberg and Kevin G. Peters* (1997). TIE2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circulation Res., 81, 567-574.
Griseldis Hübner, Maria Brauchle, Michael Gregor and Sabine Werner* (1997). Activin A: A novel player and inflammatory marker in inflammatory bowel disease? Lab. Invest., 77, 311-318.
Marianne Madlener and Sabine Werner* (1997). cDNA cloning and expression of the gene encoding mouse stromelysin-2 (MMP-10). Gene, 202, 75-81.
1996
Reinhard Fässler*, Takako Sasaki, Rupert Timpl, Mon-Li Chiu and Sabine Werner (1996). Differential regulation of fibulin, tenascin, and nidogen expression during wound healing of normal and glucocorticoid-treated mice. Exp. Cell Res., 222, 111-116.
Griseldis Hübner, Qianjin Hu, Hans Smola and Sabine Werner* (1996). Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev. Biol., 173, 490-498.
Griseldis Hübner, Maria Brauchle, Hans Smola, Marianne Madlener, Reinhard Fässler and Sabine Werner* (1996). Differential regulation of pro-inflammatory cytokines during normal and impaired wound healing. Cytokine 8, 548-556.
Stefan Frank, Marianne Madlener and Sabine Werner* (1996). Transforming growth factors b1, b2 and b3 are differentially regulated by glucocorticoids in vitro and during wound healing. J. Biol. Chem., 271, 10188-10193.
Athina Lymboussaki, Arja Kaipainen, Erika Hatva, Imre Västrik, Leila Jeskanen, Markku Jalkanen, Sabine Werner, Frej Stenbäck and Riitta Alitalo* (1996). Expression of Mad, an antagonist of Myc oncoprotein function, in differentiating keratinocytes during tumorigenesis of the skin. Brit. J. Cancer 73, 1347-1355.
Erik Forsberg, Emilio Hirsch, Leopold Fröhlich, Michael Meyer, Peter Ekblom, Attila Aszodi, Sabine Werner and Reinhard Fässler* (1996). Skin wounds and severed nerves heal normally in mice lacking tenascin-C. Proc. Natl. Acad. Sci. USA 93, 6594-6599.
Maria Brauchle, Marianne Madlener, Anna Dorothea Wagner, Karin Angermeyer, Ulrich Lauer, Peter Hans Hofschneider, Michael Gregor and Sabine Werner* (1996). Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease. Am. J. Pathol. 149, 521-529.
Yvonne Tretter, Barbara Munz, Griseldis Hübner, Gerrit ten Bruggencate, Sabine Werner and Christian Alzheimer* (1996). Strong induction of activin A expression after hippocampal injury. NeuroReport 7, 1819-1823.
Maria Brauchle, Jens-Oliver Funk, Peter Kind and Sabine Werner* (1996). UVB and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J. Biol. Chem., 271, 21793-21797.
Griseldis Hübner and Sabine Werner* (1996). Serum growth factors and pro-inflammatory cytokines are potent inducers of activin expression in cultured fibroblasts and keratinocytes. Exp. Cell Res. 228, 103-113.
Stefan Frank and Sabine Werner* (1996). The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor - regulated gene. J. Biol. Chem. 271, 24337-24340.
Sabine Werner*, Maria Brauchle, Griseldis Hübner, Stefan Frank und Hans Smola (1996). Die Funktion des Keratinocyte growth factor bei der Wundheilung. Zentralblatt für Chirurgie 121(S), 20-21.
Marianne Madlener, Cornelia Mauch, Maria Brauchle, Walter Conca, William B. Parks and Sabine Werner (1996). Growth factor regulation of stromelysin-2 expression in cultured keratinocytes: Implications for normal and impaired wound healing. Biochem. J., 320, 659-664.
1995
Matthias Melzig, Anna Wobus, Wolfgang Müller-Klieser, Dirk Breitkreutz, Sabine Werner, Petra Boukamp, A. Bader, Christof Niehrs, and Norbert Fusenig* (1995). International conference on cell interactions in malignancy, development and differentiation - Heidelberg, Germany, April 1995. J. Cancer Res. & Clin. Oncol. 121, 757-763.
Stefan Frank, Griseldis Hübner, Georg Breier, Michael T. Longaker, David Greenhalgh and Sabine Werner* (1995). Regulation of vascular endothelial growth factor expression in cultured keratinocytes: Implications for normal and impaired wound healing. J. Biol. Chem., 270, 12607-12613.
Maria Brauchle, Reinhard Fässler and Sabine Werner* (1995). Suppression of keratinocyte growth factor expression by glucocorticoids in vitro and during wound healing. J. Invest. Dermatol., 105, 579-584.
Pei-San Tsai, Sabine Werner and Richard I. Weiner* (1995). Basic fibroblast growth factor is a neurotrophic factor in GnRH neuronal cell lines. Endocrinology, 136, 3831-3838.
1994
Kevin G. Peters, Sabine Werner, Xiang Liao, Susan Wert, Jeffrey Whitsett and Lewis T. Williams* (1994). FGF receptor signaling is required for airway branching and epithelial differentiation during lung development. EMBO J., 13, 3296-3301.
Sabine Werner*, Matthew Breeden, Griseldis Hübner, David G. Greenhalgh and Michael T. Longaker (1994). Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic db/db mouse. J. Invest. Dermatol., 103, 469-473.
Arasu Chellaiah, Don McEwen, Sabine Werner, Jingsong Xu and David M. Ornitz* (1994). Fibroblast growth factor receptor 3: Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J. Biol. Chem., 269, 11620-11627.
Maria Brauchle, Karin Angermeyer, Griseldis Hübner and Sabine Werner* (1994). Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 9, 3199-3204.
Sabine Werner*, Hans Smola, Xiang Liao, Michael T. Longaker, Thomas Krieg, Peter Hans Hofschneider and Lewis T. Williams (1994). The role of KGF in morphogenesis of epithelium and re-epithelialization of wounds. Science, 266, 819-822.
1993
Sabine Werner, Wendy Weinberg, Xiang Liao, Manfred Blessing, Kevin G. Peters, Stuart Yuspa, Richard I. Weiner and Lewis T. Williams* (1993). Expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J. 12, Vol.7, 2635-2643.
1992
Sabine Werner, Dah-Shuhn R. Duan, Carlie de Vries, Kevin G. Peters, Daniel E. Johnson and Lewis T. Williams* (1992). Differential splicing in the extracellular region of FGF receptor 1 generates receptor variants with different ligand binding specificities. Mol. Cell. Biol., 12, 82-88.
Kevin G. Peters, Sabine Werner, Gloria Chen and Lewis T. Williams* (1992). Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development, 114, 133-143.
Sabine Werner, Kevin G. Peters, Michael T. Longaker, Frances Fuller-Pace, Michael Banda and Lewis T. Williams* (1992). Large induction of keratinocyte growth factor in the dermis during wound healing. Proc. Natl. Acad. Sci. USA, 89, 6896-6900.
Dah-Shuhn R. Duan, Sabine Werner and Lewis T. Williams* (1992). A naturally occurring secreted form of fibroblast growth factor receptor (FGFR) 1 binds basic FGF preferentially over acidic FGF. J. Biol. Chem., 267, 16076-16080.
Kevin G. Peters, David Ornitz, Sabine Werner and Lewis T. Williams* (1992). Unique expression pattern of the mouse FGF receptor 3 gene during organogenesis. Dev. Biol.,155, 423-430.
1991
Sabine Werner*, Petra Viehweger, Peter Hans Hofschneider and Willi Kurt Roth (1991). Low mitogenic response to EGF and TGF-alpha: A characteristic feature of cultured Kaposi's sarcoma derived cells. Oncogene 6, 59-64.
Sabine Werner*, Willi Kurt Roth, Brian Bates, Mitchell Goldfarb and Peter Hans Hofschneider (1991). Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors. Oncogene 6, 2137-2144.
Daniel E. Johnson, John Lu, Helen Chen, Sabine Werner and Lewis T. Williams* (1991). The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol. Cell. Biol., 11, 4627-4634.
1990
Sabine Werner*, Peter Hans Hofschneider, Arne Östman, Carl-Henrik Heldin and Willi Kurt Roth (1990). Cultured Kaposi's sarcoma derived cells express functional PDGF A-type and B-type receptors. Exp. Cell Res., 187, 98-103.
Carl-Georg Schirren, Willi Kurt Roth, Rüdiger Hein, Sabine Werner, Thomas Krieg and Otto Braun-Falco* (1990). Invasive migration of epidemic Kaposi's sarcoma cells in vitro. Brit. J. Dermatol., 123, 313-318.
Willi Kurt Roth*, Sabine Werner and Peter Hans Hofschneider (1990). AIDS-associated and classic Kaposi's sarcoma: Low-malignant paracrine tumors. In: Progress in AIDS Research. Statusseminar des Bundesministeriums für Forschung und Technologie.
1989
Willi Kurt Roth*, Sabine Werner, Carl Georg Schirren and Peter Hans Hofschneider (1989). Depletion of PDGF from serum inhibits growth of AIDS-related and sporadic Kaposi's sarcoma derived cells in culture. Oncogene 4, 483-487.
Sabine Werner*, Peter Hans Hofschneider and Willi Kurt Roth (1989). Cells derived from sporadic and AIDS-related Kaposi's sarcoma reveal identical cytochemical and molecular properties in vitro. Int. J. Cancer 43, 1137-1144.
Sabine Werner*, Peter Hans Hofschneider, Michael Stürzl, Irene Dick and Willi Kurt Roth (1989). Cytochemical and molecular properties of SV40 transformed Kaposi's sarcoma derived cells: Evidence for the secretion of a member of the fibroblast growth factor family. J. Cell Physiol. 141, 490-502.
1988
Sabine Werner*, Wolfgang Klump, Heike Schönke, Peter Hans Hofschneider and Reinhard Kandolf (1988). Expression of Coxsackievirus B3 capsid proteins in Escherichia coli and generation of virus-specific antisera. DNA 7, 307-316.
Willi Kurt Roth*, Sabine Werner, Angelika Hemmerling, Klaus Remberger, Karl-Heinz Marquardt and Peter Hans Hofschneider (1988). Kaposi's sarcoma: Cytological and molecularbiological characterization. AIFO 11, 644-647.
Willi Kurt Roth*, Sabine Werner, Werner Risau, Klaus Remberger and Peter Hans Hofschneider (1988). Cultured, AIDS-related Kaposi's sarcoma derived cells express endothelial cell markers and are weakly malignant in vitro. Int. J. Cancer 42, 767-773.
Sabine Werner, Heike Schönke, Wolfgang Klump, Peter Hans Hofschneider and Reinhard Kandolf* (1988). Generation of enterovirus group-specific antisera using bacterially synthesized Coxsackievirus B3 proteins. In: New concepts in viral heart disease. H.-P. Schultheiß ed. Springer Verlag, pp 125-136.